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Title: | The causes and consequences of mIR-503 dysregulation and its impact on cardiovascular disease and cancer | Authors: | He, Y Cai, Y Pai, PM Ren, X Xia, Z |
Issue Date: | Mar-2021 | Source: | Frontiers in pharmacology, Mar. 2021, v. 12, 629611 | Abstract: | microRNAs (miRs) are short, non-coding RNAs that regulate gene expression by mRNA degradation or translational repression. Accumulated studies have demonstrated that miRs participate in various biological processes including cell differentiation, proliferation, apoptosis, metabolism and development, and the dysregulation of miRs expression are involved in different human diseases, such as neurological, cardiovascular disease and cancer. microRNA-503 (miR-503), one member of miR-16 family, has been studied widely in cardiovascular disease and cancer. In this review, we summarize and discuss the studies of miR-503 in vitro and in vivo, and how miR-503 regulates gene expression from different aspects of pathological processes of diseases, including carcinogenesis, angiogenesis, tissue fibrosis and oxidative stress; We will also discuss the mechanisms of dysregulation of miR-503, and whether miR-503 could be applied as a diagnostic marker or therapeutic target in cardiovascular disease or cancer. | Keywords: | Angiogenesis Cancer Cardiovascular disease MicroRNA-503 MicroRNAs Oxidative stress |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in pharmacology | EISSN: | 1663-9812 | DOI: | 10.3389/fphar.2021.629611 | Rights: | © 2021 He, Cai, Pai, Ren and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms The following publication He Y, Cai Y, Pai PM, Ren X and Xia Z (2021) The Causes and Consequences of miR-503 Dysregulation and Its Impact on Cardiovascular Disease and Cancer. Front. Pharmacol. 12:629611 is available at https://doi.org/10.3389/fphar.2021.629611 |
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