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Title: | Recent advances in differentiation of isomers by ion mobility mass spectrometry | Authors: | Wu, Q Wang, JY Han, DQ Yao, ZP |
Issue Date: | Mar-2020 | Source: | Trends in analytical chemistry, Mar. 2020, v. 124, 115801 | Abstract: | Differentiation of isomers is an important analytical task in many fields, e.g., chemistry, biology, pharmaceutical science, medicine, environmental science, food science. Ion mobility mass spectrometry (IM-MS) can resolve isobaric ions based on their shape and size and measure the collision cross section (CCS) values of ions to provide information on their intrinsic structures, and is thus a very promising tool for differentiation of isomers. In this review, the applications of IM-MS in differentiation of various isomers including glycans, lipids, amino acids, peptides, proteins, as well as metabolite isomers, chiral isomers, etc. are summarized. Prospects for further development of IM-MS for differentiation of isomers, e.g., improved resolving powers of IM-MS instruments and measurement reproducibility, expanded CCS database and coupling of IM-MS with computational approaches, are also discussed. | Keywords: | Differentiation Ion mobility Isomer Mass spectrometry |
Publisher: | Elsevier BV | Journal: | Trends in analytical chemistry | ISSN: | 0165-9936 | DOI: | 10.1016/j.trac.2019.115801 | Rights: | © 2019 Elsevier B.V. All rights reserved. © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. The following publication Wu, Q., Wang, J.-Y., Han, D.-Q., & Yao, Z.-P. (2020). Recent advances in differentiation of isomers by ion mobility mass spectrometry. TrAC Trends in Analytical Chemistry, 124, 115801 is available at https://dx.doi.org/10.1016/j.trac.2019.115801. |
Appears in Collections: | Journal/Magazine Article |
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Wu_Isomers_Ion_Mobility.pdf | Pre-Published version | 1.3 MB | Adobe PDF | View/Open |
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