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http://hdl.handle.net/10397/89822
Title: | Design of functional chiral cyclen-based radiometal chelators for theranostics | Authors: | Dai, L Zhang, J Wong, CT Chan, WTK Ling, X Anderson, CJ Law, GL |
Issue Date: | 17-May-2021 | Source: | Inorganic chemistry, 17 May 2021, v. 60, no. 10, p. 7082-7088 | Abstract: | A series of water-soluble chiral cyclen-based chelators with chemical handles for selective targeting have been synthesized (cyclen = 1,4,7,10-Tetraazacyclododecane). Optical studies, relaxivity measurements, and competitive titrations were performed to show the versatility of these chiral chelators. The complexations of L3, L4, and L5 with Lu3+, Y3+, Sc3+, and Cu2+ were successfully demonstrated in around 90% to 100% yields. Efficient and rapid radiolabeling of L5 with 177Lu was achieved under mild conditions with 96% yield. The chelators exhibit near quantitative labeling efficiencies with a wide range of radiometal ions, which are promising for the development of targeting specific radiopharmaceutical and molecular magnetic resonance imaging contrast agents. | Publisher: | American Chemical Society | Journal: | Inorganic chemistry | ISSN: | 0020-1669 | DOI: | 10.1021/acs.inorgchem.0c03734 | Rights: | © 2021 American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in Inorganic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.inorgchem.0c03734. |
Appears in Collections: | Journal/Magazine Article |
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Dai_Functional_Chiral_Cyclen-Based.pdf | Pre-Published version | 1.82 MB | Adobe PDF | View/Open |
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