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http://hdl.handle.net/10397/89817
Title: | Adiporon treatment induces a dose‐dependent response in adult hippocampal neurogenesis | Authors: | Lee, TH Christie, BR van, Praag, H Lin, K Siu, PMF Xu, A So, KF Yau, SY |
Issue Date: | Feb-2021 | Source: | International journal of molecular sciences, 2 Feb. 2021, v. 22, no. 4, 2068, p. 1-15 | Abstract: | AdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti–atherogenic, and anti–inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross the blood–brain barrier, its chronic effects on regulating hippocampal function are yet to be examined. This study investigated whether AdipoRon treatment promotes hippocampal neurogenesis and spatial recognition memory in a dose–dependent manner. Adolescent male C57BL/6J mice received continuous treatment of either 20 mg/kg (low dose) or 50 mg/kg (high dose) AdipoRon or vehicle intraperitoneally for 14 days, followed by the open field test to examine anxiety and locomotor ac-tivity, and the Y maze test to examine hippocampal–dependent spatial recognition memory. Im-munopositive cell markers of neural progenitor cells, immature neurons, and newborn cells in the hippocampal dentate gyrus were quantified. Immunosorbent assays were used to measure the serum levels of factors that can regulate hippocampal neurogenesis, including adiponectin, brain– derived neurotrophic factor (BDNF), and corticosterone. Our results showed that 20 mg/kg Adipo‐ Ron treatment significantly promoted hippocampal cell proliferation and increased serum levels of adiponectin and BDNF, though there were no effects on spatial recognition memory and locomotor activity. On the contrary, 50 mg/kg AdipoRon treatment impaired spatial recognition memory, sup-pressed cell proliferation, neuronal differentiation, and cell survival associated with reduced serum levels of BDNF and adiponectin. The results suggest that a low‐dose AdipoRon treatment promotes hippocampal cell proliferation, while a high–dose AdipoRon treatment is detrimental to the hippo-campus function. | Keywords: | Adiponectin AdipoRon Brain–de-rived neurotrophic factor Hippocampal neurogenesis Learning and memory |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | International journal of molecular sciences | ISSN: | 1661-6596 | EISSN: | 1422-0067 | DOI: | 10.3390/ijms22042068 | Rights: | © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/). The following publication Lee TH, Christie BR, van Praag H, Lin K, Siu PM-F, Xu A, So K-F, Yau S-y. AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis. International Journal of Molecular Sciences. 2021; 22(4):2068 is available at https://doi.org/10.3390/ijms22042068 |
Appears in Collections: | Journal/Magazine Article |
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