Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89622
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Yeung, MK | en_US |
dc.creator | Tsuchida, A | en_US |
dc.creator | Fellows, LK | en_US |
dc.date.accessioned | 2021-04-13T06:08:57Z | - |
dc.date.available | 2021-04-13T06:08:57Z | - |
dc.identifier.issn | 0898-929X | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/89622 | - |
dc.language.iso | en | en_US |
dc.publisher | MIT Press | en_US |
dc.rights | © 2020 Massachusetts Institute of Technology | en_US |
dc.rights | This is the author’s final version and that the article has been accepted for publication in Journal of Cognitive Neuroscience. | en_US |
dc.rights | The following publication Michael K. Yeung, Ami Tsuchida, Lesley K. Fellows; Causal Prefrontal Contributions to Stop-Signal Task Performance in Humans. J Cogn Neurosci 2021; 33 (9): 1784–1797 is available at https://doi.org/10.1162/jocn_a_01652. The Journal of Cognitive Neuroscience is available at https://direct.mit.edu/jocn. | en_US |
dc.title | Causal prefrontal contributions to stop-signal task performance in humans | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1784 | en_US |
dc.identifier.epage | 1797 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.doi | 10.1162/jocn_a_01652 | en_US |
dcterms.abstract | The frontal lobes have long been implicated in inhibitory control, but a full understanding of the underlying mechanisms remains elusive. The stop-signal task has been widely used to probe instructed response inhibition in cognitive neuroscience. The processes involved have been modeled and related to putative brain substrates. However, there has been surprisingly little human lesion research using this task, with the few existing studies implicating different prefrontal regions. Here, we tested the effects of focal prefrontal damage on stop-signal task performance in a large sample of people with chronic focal damage affecting the frontal lobes (n = 42) and demographically matched healthy people (n = 60). Patients with damage to the left lateral, right lateral, dorsomedial, or ventromedial frontal lobe had slower stop-signal RT compared to healthy controls. There were systematic differences in the patterns of impairment across frontal subgroups: Those with damage to the left or right lateral and dorsomedial frontal lobes, but not those with ventromedial frontal damage, were slower than controls to “go” as well as to stop. These findings suggest that multiple prefrontal regions make necessary but distinct contributions to stop-signal task performance. As a consequence, stop-signal RT slowing is not strongly localizing within the frontal lobes. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of cognitive neuroscience, Sept 2021, v. 33, no. 9, p. 1784-1797 | en_US |
dcterms.isPartOf | Journal of cognitive neuroscience | en_US |
dcterms.issued | 2021-09 | - |
dc.identifier.scopus | 2-s2.0-85112701655 | - |
dc.identifier.eissn | 1530-8898 | en_US |
dc.description.validate | 202104 bcvc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | a0719-n04 | - |
dc.identifier.SubFormID | 1061 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1061_Yeung_et_al._2020_JoCN.pdf | Pre-Published version | 2.05 MB | Adobe PDF | View/Open |
Page views
92
Last Week
0
0
Last month
Citations as of Apr 28, 2024
Downloads
132
Citations as of Apr 28, 2024
SCOPUSTM
Citations
3
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
2
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.