Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89186
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Fang, X | en_US |
dc.creator | Wu, X | en_US |
dc.creator | Li, Z | en_US |
dc.creator | Jiang, L | en_US |
dc.creator | Lo, WS | en_US |
dc.creator | Chen, G | en_US |
dc.creator | Gu, Y | en_US |
dc.creator | Wong, WT | en_US |
dc.date.accessioned | 2021-02-04T02:40:06Z | - |
dc.date.available | 2021-02-04T02:40:06Z | - |
dc.identifier.issn | 2198-3844 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/89186 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2020 The Authors. Published by Wiley‐VCH GmbH | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication X. Fang, X. Wu, Z. Li, L. Jiang, W.-S. Lo, G. Chen, Y. Gu, W.-T. Wong, Biomimetic Anti-PD-1 Peptide-Loaded 2D FePSe3 Nanosheets for Efficient Photothermal and Enhanced Immune Therapy with Multimodal MR/PA/Thermal Imaging. Adv. Sci. 2021, 8, 2003041 is available at https://dx.doi.org/10.1002/advs.202003041 | en_US |
dc.subject | Cancer photothermal�Immune therapy | en_US |
dc.subject | Fepse3 nanosheets | en_US |
dc.subject | Metal phosphorus trichalcogenides | en_US |
dc.subject | Multimodal imaging | en_US |
dc.subject | Pd-1 blockade | en_US |
dc.title | Biomimetic anti-PD-1 peptide-loaded 2D FePSe3 nanosheets for efficient photothermal and enhanced immune therapy with multimodal MR/PA/thermal imaging | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.doi | 10.1002/advs.202003041 | en_US |
dcterms.abstract | Metal phosphorous trichalcogenides (MPX3) are novel 2D nanomaterials that have recently been exploited as efficient photothermal–chemodynamic agents for cancer therapy. As a representative MPX3, FePSe3 has the potential to be developed as magnetic resonance imaging (MRI) and photoacoustic imaging (PAI) agents due to the composition of Fe and the previously revealed PA signal. Here, a FePSe3-based theranostic agent, FePSe3@APP@CCM, loaded with anti-PD-1 peptide (APP) as the inner component and CT26 cancer cell membrane (CCM) as the outer shell is reported, which acts as a multifunctional agent for MR and PA imaging and photothermal and immunotherapy against cancer. FePSe3@APP@CCM induces highly efficient tumor ablation and suppresses tumor growth by photothermal therapy under near-infrared laser excitation, which further activates immune responses. Moreover, APP blocks the PD-1/PD-L1 pathway to activate cytotoxic T cells, causing strong anticancer immunity. The combined therapy significantly prolongs the lifespan of experimental mice. The multimodal imaging and synergistic therapeutic effects of PTT and its triggered immune responses and APP-related immunotherapy are clearly demonstrated by in vitro and in vivo experiments. This work demonstrates the potential of MPX3-based biomaterials as novel theranostic agents. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 20 Jan. 2021, v. 8, no. 2, 2003041 | en_US |
dcterms.isPartOf | Advanced science | en_US |
dcterms.issued | 2021-01-20 | - |
dc.identifier.isi | WOS:000591883200001 | - |
dc.identifier.scopus | 2-s2.0-85096742851 | - |
dc.identifier.artn | 2003041 | en_US |
dc.description.validate | 202101 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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advs.202003041.pdf | 5.68 MB | Adobe PDF | View/Open |
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