Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89144
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Lin, D | - |
dc.creator | Chen, K | - |
dc.creator | Guo, J | - |
dc.creator | Ye, L | - |
dc.creator | Li, R | - |
dc.creator | Chan, EWC | - |
dc.creator | Chen, S | - |
dc.date.accessioned | 2021-02-04T02:39:43Z | - |
dc.date.available | 2021-02-04T02:39:43Z | - |
dc.identifier.issn | 1949-0976 | - |
dc.identifier.uri | http://hdl.handle.net/10397/89144 | - |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. | en_US |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Lin, D., Chen, K., Guo, J., Ye, L., Li, R., Chan, E. W. C., & Chen, S. (2020). Contribution of biofilm formation genetic locus, pgaABCD, to antibiotic resistance development in gut microbiome. Gut Microbes, 12(1), 1-12 is available at https://dx.doi.org/10.1080/19490976.2020.1842992 | en_US |
dc.subject | Antimicrobial resistance progenitor cells | en_US |
dc.subject | Escherichia coli | en_US |
dc.subject | Microbiome | en_US |
dc.subject | Sub-species diversity | en_US |
dc.title | Contribution of biofilm formation genetic locus, pgaABCD, to antibiotic resistance development in gut microbiome | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 12 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1080/19490976.2020.1842992 | - |
dcterms.abstract | The human gut microbiome is the presumed site in which the emergence and evolution of antibiotic-resistant organisms constantly take place. To delineate the genetic basis of resistance formation in gut microbiome strains, we investigated the changes in the subpopulation structure of Escherichia coli in rat intestine before and after antimicrobial treatment. We observed that antibiotic treatment was selected for an originally minor subpopulation E. coli carrying the biofilm-forming genetic locus pgaABCD and the toxin-antitoxin system HipAB. Such strains possessed dramatically enhanced ability to withstand the detrimental effects of antibiotics, becoming a dominant subspecies upon antibiotic treatment and eventually evolving into resistant mutants. In contrast, E. coli strains that did not carry pgaABCD and HipAB were eradicated upon antibiotic treatment. Our findings, therefore, suggested that genes encoding biofilm-forming ability played an important role in conferring specific gut E. coli strains the ability to evolve into resistant strains upon a prolonged antibiotic treatment, and that such strains may therefore be considered bacterial antibiotic resistance progenitor cells in the gut microbiome. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Gut microbes, 2020, v. 12, no. 1, p. 1-12 | - |
dcterms.isPartOf | Gut microbes | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000594298600001 | - |
dc.identifier.scopus | 2-s2.0-85096004517 | - |
dc.identifier.pmid | 33190591 | - |
dc.identifier.eissn | 1949-0984 | - |
dc.description.validate | 202101 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Lin_Contribution_Biofilm_Formation.pdf | 3.86 MB | Adobe PDF | View/Open |
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