Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89113
Title: | Effects of Cd-based quantum dot exposure on the reproduction and offspring of kunming mice over multiple generations | Authors: | Liu, J Yang, C Liu, J Hu, R Hu, Y Chen, H Law, WC Swihart, MT Ye, L Wang, K Yong, KT |
Issue Date: | 2017 | Source: | Nanotheranostics, 2017, v. 1, no. 1, p. 23-37 | Abstract: | The potential health risks associated with heavy-metal containing quantum dots (QDs) are a major concern accompanying their increased application in both research and industry. In this contribution, we investigate the effects of QDs on reproductive outcomes in Kunming mice across three generations. Rather than being exposed to QDs during pregnancy, mice were intravenously injected with phospholipid micelle encapsulated CdSe/CdS/ZnS QDs at a dosage of 0.81 mg Cd/kg two weeks before mating. Four treatment groups were studied: non-injected control, female injected, male injected and both parents injected with QDs. Although QDs accumulated in the major organs of treated mice, we did not detect any pregnancy complications or adverse effects. No significant difference in pregnancy outcomes could be identified between the QD treated groups and the control group. More importantly, through behavior monitoring, blood tests and histological evaluations, two generations of the offspring were observed to be in normal and healthy condition. Our results show that QD exposure with a short buffering period before conception does not cause obvious pregnancy complications or significant toxicity effects in treated mice or their offspring. This indicates that a short buffering period after QD exposure may reduce potential risk of QDs to reproductive health. | Keywords: | Offspring Quantum dots Reproductive health Toxicity |
Publisher: | Ivyspring International Publisher | Journal: | Nanotheranostics | ISSN: | 2206-7418 | DOI: | 10.7150/ntno.17753 | Rights: | © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. The following publication Liu, J., Yang, C., Liu, J., Hu, R., Hu, Y., Chen, H., . . . Yong, K. -. (2017). Effects of cd-based quantum dot exposure on the reproduction and offspring of kunming mice over multiple generations. Nanotheranostics, 1(1), 23-37 is available at https://dx.doi.org/10.7150/ntno.17753 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
v01p0023.pdf | 5.02 MB | Adobe PDF | View/Open |
Page views
63
Last Week
4
4
Last month
Citations as of Apr 28, 2024
Downloads
20
Citations as of Apr 28, 2024
SCOPUSTM
Citations
19
Citations as of Apr 4, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.