Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/89080
Title: | Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs | Authors: | Lai, WF Huang, E Lui, KH |
Issue Date: | Jan-2021 | Source: | Asian journal of pharmaceutical sciences, Jan. 2021, v. 16, no. 1, p. 77-85 | Abstract: | Hydrogels are soft materials consisting of a three-dimensional network of polymer chains. Over the years, hydrogels with different compositions have been developed as drug carriers for diverse biomedical applications, ranging from cancer therapy and wound care to the treatment of neurodegenerative and inflammatory diseases. Most of these carriers, however, are designed only to deliver single agents. Carriers based on hydrogels for co-delivery of multiple agents, with the release rate of each of the co-delivered agents tunable, are lacking. This study reports a one-pot method of fabricating alginate-based complex fibers with the Janus morphology, with carboxymethyl cellulose sodium functioning as a polymeric modifier of the properties of each of the fiber compartments. By using malachite green and minocycline hydrochloride as model drugs, the generated fibers demonstrate the capacity of enabling the release profile of each of the co-delivered drugs to be precisely controlled. Along with their negligible toxicity and the retention of the activity of the loaded drugs, the complex fibers reported in this study warrant further development and optimization for applications that involve co-delivery of multiple agents. | Keywords: | Co-Delivery Complex fiber Controlled release Janus morphology Tunable release profiles |
Publisher: | Elsevier | Journal: | Asian journal of pharmaceutical sciences | ISSN: | 1818-0876 | DOI: | 10.1016/j.ajps.2020.05.003 | Rights: | © 2021 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Ain Shams University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Lai, W.-F., Huang, E., & Lui, K.-H. (2021). Alginate‐based complex fibers with the Janus morphology for controlled release of co‐delivered drugs. Asian Journal of Pharmaceutical Sciences, 16(1), 77-85 is available at https://dx.doi.org/10.1016/j.ajps.2020.05.003 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S1818087620302841-main.pdf | 2.52 MB | Adobe PDF | View/Open |
Page views
42
Last Week
0
0
Last month
Citations as of Apr 28, 2024
Downloads
36
Citations as of Apr 28, 2024
SCOPUSTM
Citations
82
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
80
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.