Stratification analysis and case-control study of relationships between interleukin-6 gene polymorphisms and cervical cancer risk in a Chinese population

Abstract

Interleukin-6 (IL-6), a central proinflammatory cytokine, maintains immune homeostasis and also plays important roles in cervical cancer. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms at positions -174 and -572 with predisposition to cervical cancer in a Chinese population. The present hospital-based case-control study comprised 518 patients with cervical cancer and 518 healthy controls. Polymorphisms of the IL-6 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Patients with cervical cancer had a significantly higher frequency of the IL-6-174 CC genotype [odds ratio (OR) = 1.52, 95% confidence interval (CI) = 1.06-2.19; p=0.02], IL-6-572 CC genotype (OR = 1.91, 95% CI = 1.16-3.13; p=0.01) and IL-6-174 C allele (OR = 1.21, 95% CI = 1.02-1.44; p=0.03) compared to healthy controls. When stratifying by the FIGO stage, patients with III-IV cervical cancer had a significantly higher frequency of IL-6-174 CC genotype (OR = 1.64, 95% CI = 1.04-2.61; p= 0.04). The CC genotypes of the IL-6 gene polymorphisms at positions-174 and-572 may confer a high risk of cervical cancer. Additional studies with detailed human papillomavirus (HPV) infection data are warranted to validate our findings.