Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/88908
Title: Stratification analysis and case-control study of relationships between interleukin-6 gene polymorphisms and cervical cancer risk in a Chinese population
Authors: Shi, WJ
Liu, H 
Wu, D
Tang, ZH
Shen, YC
Guo, L
Issue Date: 2014
Source: Asian Pacific journal of cancer prevention, 2014, v. 15, no. 17, p. 7357-7362
Abstract: Interleukin-6 (IL-6), a central proinflammatory cytokine, maintains immune homeostasis and also plays important roles in cervical cancer. Therefore, we aimed to evaluate any associations of IL-6 gene polymorphisms at positions -174 and -572 with predisposition to cervical cancer in a Chinese population. The present hospital-based case-control study comprised 518 patients with cervical cancer and 518 healthy controls. Polymorphisms of the IL-6 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Patients with cervical cancer had a significantly higher frequency of the IL-6-174 CC genotype [odds ratio (OR) = 1.52, 95% confidence interval (CI) = 1.06-2.19; p=0.02], IL-6-572 CC genotype (OR = 1.91, 95% CI = 1.16-3.13; p=0.01) and IL-6-174 C allele (OR = 1.21, 95% CI = 1.02-1.44; p=0.03) compared to healthy controls. When stratifying by the FIGO stage, patients with III-IV cervical cancer had a significantly higher frequency of IL-6-174 CC genotype (OR = 1.64, 95% CI = 1.04-2.61; p= 0.04). The CC genotypes of the IL-6 gene polymorphisms at positions-174 and-572 may confer a high risk of cervical cancer. Additional studies with detailed human papillomavirus (HPV) infection data are warranted to validate our findings.
Keywords: Interleukin-6
Cervical cancer
Gene polymorphism
Risk
Chinese females
Publisher: Asian Pacific Organization for Cancer Prevention
Journal: Asian Pacific journal of cancer prevention 
EISSN: 1513-7368
DOI: 10.7314/APJCP.2014.15.17.7357
Rights: This is an open access article under the Creative Commons Attribution License. This permits anyone to copy, distribute, transmit and adapt the published work, provided the original work and source are appropriately cited.
The following publication Shi, W. J., Liu, H., Wu, D., Tang, Z. H., Shen, Y. C., & Guo, L. (2014). Stratification analysis and case-control study of relationships between interleukin-6 gene polymorphisms and cervical cancer risk in a Chinese population. Asian Pac J Cancer Prev, 15(17), 7357-7362 , is available at https://doi.org/10.7314/APJCP.2014.15.17.7357
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