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Title: | PMQR genes oqxAB and aac(6 ')Ib-cr accelerate the development of fluoroquinolone resistance in Salmonella typhimurium | Authors: | Wong, MH Chan, EW Liu, LZ Chen, S |
Issue Date: | 2-Oct-2014 | Source: | Frontiers in microbiology, 2 Oct. 2014, v. 5, 521, p. 1-7 | Abstract: | Emergence of multidrug-resistant Salmonella typhimurium strains, especially the ACSSuT and nalidixic acid R types, has significantly compromised the effectiveness of current strategies to control Salmonella infections, resulting in increased morbidity and mortality. Clinical S. typhimurium isolates recovered in Hong Kong during the period of 2005-2011 were increasingly resistant to ciprofloxacin (CIP) and antibiotics of the ACSSuT group. Our data revealed that oqxAB and aac(6')Ib-cr were encoded on plasmids of various sizes and the presence of these two elements together with a single gyrA mutation in S. typhimunum were sufficient to mediate resistance to CIP. Acquisition of the oqxAB and aac(6')Ib-cr encoding plasmids by S. typhimurium caused a fourfold increase in CIP minimal inhibitory concentration. Furthermore, the presence of oqxAB and aac(6')Ib-cr in Salmonella dramatically increased the mutation prevention concentration of CIP which may due to mutational changes in the drug target genes. In conclusion, possession of oqxAB and aac(6')Ib-cr encoding plasmid facilitate the selection of CIP resistant S. typhimurium, thereby causing a remarkable increase of CIP resistance among clinical Salmonella strains in Hong Kong. | Keywords: | S. typhimurium Ciprofloxacin resistance ACSSuT R type oqxAB aac(6 ')Ib-cr |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in microbiology | ISSN: | 1664-302X | DOI: | 10.3389/fmicb.2014.00521 | Rights: | Copyright © 2014 Wong, Chan, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Wong, M. H., Chan, E. W., Liu, L. Z., & Chen, S. (2014). PMQR genes oqxAB and aac(6 ')Ib-cr accelerate the development of fluoroquinolone resistance in Salmonella typhimurium. Frontiers In Microbiology, 5, 521, 1-7 is available at https://dx.doi.org/10.3389/fmicb.2014.00521 |
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