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http://hdl.handle.net/10397/88750
Title: | Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters | Authors: | So, KF Leung, MCP Cui, Q |
Issue Date: | Nov-2014 | Source: | Neural regeneration research, Nov. 2014, , v. 9, no. 21, p. 1863-1869 | Abstract: | Injury to axons close to the neuronal bodies in the mammalian central nervous system causes a large proportion of parenting neurons to degenerate. It is known that optic nerve transection close to the eye in rodents leads to a loss of about half of retinal ganglion cells in 1 week and about 90% in 2 weeks. Using low level laser treatment in the present study, we demonstrated that treatment with helium-neon (660 nm) laser with 15 mW power could delay retinal ganglion cell death after optic nerve axotomy in adult hamsters. The effect was most apparent in the first week with a short period of treatment time (5 minutes) in which 65-66% of retinal ganglion cells survived the optic nerve axotomy whereas 45-47% of retinal ganglion cells did so in optic nerve axotomy controls. We also found that single dose and early commencement of laser irradiation were important in protecting retinal ganglion cells following optic nerve axotomy. These findings thus convincingly show that appropriate laser treatment may be neuroprotective to retinal ganglion cells. | Keywords: | Low level laser treatment Retinal ganglion cells Optic nerve injury Neuroprotection Microglial proliferation Optic nerve axotomy |
Publisher: | Medknow Publications and Media Pvt Ltd | Journal: | Neural regeneration research | ISSN: | 1673-5374 | DOI: | 10.4103/1673-5374.145337 | Rights: | This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License (https://creativecommons.org/licenses/by-nc-sa/4.0/), which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. The following publication So KF, Leung MCP, Cui Q. Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters. Neural Regen Res. 2014;9(21):1863-1869 is available at https://dx.doi.org/10.4103/1673-5374.145337 |
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