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http://hdl.handle.net/10397/88719
Title: | Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome? : a comparative study of true and sham acupuncture using functional magnetic resonance imaging | Authors: | Chu, WCW Wu, JCY Yew, DTW Zhang, L Shi, L Yeung, DKW Wang, DF Tong, RKY Chan, YW Lao, LX Leung, PC Berman, BM Sung, JJY |
Issue Date: | Jul-2012 | Source: | Journal of neurogastroenterology and motility, July 2012, , v. 18, no. 3, p. 305-316 | Abstract: | Background/Aims Patients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model. Methods Thirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program. Results Rectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture. Conclusions We postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus. |
Keywords: | Acupuncture Irritable bowel syndrome Magnetic resonance imaging |
Publisher: | Korean Society of Neurogastroenterology and Motility, Daehan Sohwagwan Undong Haghoe | Journal: | Journal of neurogastroenterology and motility | ISSN: | 2093-0879 | EISSN: | 2093-0887 | DOI: | 10.5056/jnm.2012.18.3.305 | Rights: | © The Korean Society of Neurogastroenterology and Motility. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The following publication Chu WC, Wu JC, Yew DT, Zhang L, Shi L, Yeung DK, Wang D, Tong RK, Chan Y, Lao L, Leung PC, Berman BM, Sung JJ. Does Acupuncture Therapy Alter Activation of Neural Pathway for Pain Perception in Irritable Bowel Syndrome?: A Comparative Study of True and Sham Acupuncture Using Functional Magnetic Resonance Imaging. J Neurogastroenterol Motil 2012;18:305-316 is available at https://dx.doi.org/10.5056/jnm.2012.18.3.305 |
Appears in Collections: | Journal/Magazine Article |
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