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http://hdl.handle.net/10397/88679
Title: | Single-shot linear dichroism optical-resolution photoacoustic microscopy | Authors: | Zhou, YY Chen, JB Liu, C Liu, CB Lai, PX Wang, LD |
Issue Date: | Dec-2019 | Source: | Photoacoustics, Dec. 2019, v. 16, 100148, p. 1-5 | Abstract: | Dichroism is a material property that causes anisotropic light-matter interactions for different optical polarizations. Dichroism relates to molecular types and material morphology and thus can be used to distinguish different dichroic tissues. In this paper, we present single-shot dichroism photoacoustic microscopy that can image tissue structure, linear dichroism, and polarization angle with a single raster scanning. We develop a fiber-based laser system to split one laser pulse into three with different polarization angles, sub-microseconds time delay, and identical pulse energy. A dual-fiber optical-resolution photoacoustic microscopy system is developed to acquire three A-lines per scanning step. In such a way, dichroism imaging can achieve the same speed as single-wavelength photoacoustic microscopy. Moreover, the three polarized pulses originate from one laser pulse, which decreases pulse energy fluctuations and reduces dichroism measurement noise by similar to 35 %. The new dichroism photoacoustic imaging technique can be used to image endogenous or exogenous polarization-dependent absorption contrasts, such as dichroic tumor or molecule-labeled tissue. | Keywords: | Linear dichroism Photoacoustic microscopy Polarization |
Publisher: | Elsevier | Journal: | Photoacoustics | ISSN: | 2213-5987 | EISSN: | 2213-5979 | DOI: | 10.1016/j.pacs.2019.100148 | Rights: | © 2019 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). The following publication Zhou, Y. Y., Chen, J. B., Liu, C., Liu, C. B., Lai, P. X., & Wang, L. D. (2019). Single-shot linear dichroism optical-resolution photoacoustic microscopy. Photoacoustics, 16, 100148, 1-5 is available at https://dx.doi.org/10.1016/j.pacs.2019.100148 |
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Zhou_Single-Shot_Linear_Dichroism.pdf | 1.43 MB | Adobe PDF | View/Open |
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