Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88532
Title: | Effects of childhood adversity and its interaction with the MAOA, BDNF, and COMT polymorphisms on subclinical attention deficit/hyperactivity symptoms in generally healthy youth | Authors: | Tsai, MC Jhang, KJ Lee, CT Lin, YF Strong, C Lin, YC Hsieh, YP Lin, CY |
Issue Date: | Sep-2020 | Source: | Children, Sept. 2020, v. 7, no. 9, 122, p. 1-12 | Abstract: | We aimed to investigate the effects of childhood adversity and its interaction with the polymorphisms in the monoamine oxidase A (MAOA), brain-derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) genes on attention and hyperactivity disorder (ADHD) symptoms in a community sample of generally healthy youth. Participants (N = 432) completed questionnaires assessing ADHD symptoms (i.e., inattention, hyperactivity, and impulsiveness) and adverse childhood experiences, such as adverse environments (AEs) and childhood maltreatment (CM). Salivary genomic DNA was used to test polymorphisms in MAOA, BDNF, and COMT genes. A gene score (GS) was created based on the number of risk allele in the studied genes. Multiple linear regressions were used to examine the genetic and environmental effects on ADHD symptoms. The univariate analysis indicated that CM was significantly associated with inattention (beta = 0.48 [95% confidence interval 0.16-0.79]), hyperactivity (0.25 [0.06-0.45]), and impulsiveness (1.16 [0.26-2.05]), while the GS was associated with hyperactivity (0.22 [0.11-0.33]) and impulsiveness (0.56 [0.06-1.05]). Only the GS remained significantly associated with hyperactivity (0.25 [0.12-0.37]) and impulsiveness (0.79 [0.20-1.38]) when the gene-environment interaction term was added in the model. No effects were found for AE and the gene-environment interaction term. In conclusion, CM was associated with ADHD symptoms in emerging adulthood. Genetic factors may also play a significant role in the association with these outcomes. | Keywords: | Childhood adversity Attention deficit Hyperactivity Impulsiveness Gene-Environment interaction |
Publisher: | MDPI | Journal: | Children | EISSN: | 2227-9067 | DOI: | 10.3390/children7090122 | Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). The following publication Tsai, M.-C.; Jhang, K.-J.; Lee, C.-T.; Lin, Y.-F.; Strong, C.; Lin, Y.-C.; Hsieh, Y.-P.; Lin, C.-Y. Effects of Childhood Adversity and Its Interaction with the MAOA, BDNF, and COMT Polymorphisms on Subclinical Attention Deficit/Hyperactivity Symptoms in Generally Healthy Youth. Children 2020, 7, 122 is available at https://dx.doi.org/10.3390/children7090122 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tsai_Childhood_Adversity_MAOA.pdf | 240.46 kB | Adobe PDF | View/Open |
Page views
53
Last Week
0
0
Last month
Citations as of Sep 22, 2024
Downloads
11
Citations as of Sep 22, 2024
SCOPUSTM
Citations
4
Citations as of Sep 26, 2024
WEB OF SCIENCETM
Citations
5
Citations as of Sep 26, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.