Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88378
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Tse, SPK | en_US |
dc.creator | Lee, FWF | en_US |
dc.creator | Mak, DYL | en_US |
dc.creator | Kong, HK | en_US |
dc.creator | Chan, KKY | en_US |
dc.creator | Lo, PY | en_US |
dc.creator | Lo, SCL | en_US |
dc.date.accessioned | 2020-10-29T01:02:49Z | - |
dc.date.available | 2020-10-29T01:02:49Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/88378 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Tse S -K, Lee F -F, Mak D -L, Kong H-K, Chan K -Y, Lo P-Y, Lo S -L. Production of Paralytic Shellfish Toxins (PSTs) in Toxic Alexandrium catenella is Intertwined with Photosynthesis and Energy Production. Toxins. 2020; 12(8):477, is available at https://doi.org/10.3390/toxins12080477 | en_US |
dc.subject | Alexandrium catenella | en_US |
dc.subject | Light availability | en_US |
dc.subject | Paralytic shellfish toxins | en_US |
dc.subject | Phosphate limitation | en_US |
dc.subject | Proteomics | en_US |
dc.subject | PSTs | en_US |
dc.title | Production of Paralytic Shellfish Toxins (PSTs) in toxic alexandrium catenella is intertwined with photosynthesis and energy production | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.doi | 10.3390/toxins12080477 | en_US |
dcterms.abstract | To investigate the mechanism for the production of paralytic shellfish toxins (PST) in toxic dinoflagellates, with a 2D-gel based approach, we had made two sets of proteomic comparisons: (a) between a toxic Alexandrium catenella (AC-T) and a phylogenetically closely related non-toxic strain (AC-N), (b) between toxic AC-T grown in a medium with 10% normal amount of phosphate (AC-T-10%P) known to induce higher toxicity and AC-T grown in normal medium. We found that photosynthesis and energy production related proteins were up-regulated in AC-T when compared to AC-N. However, the same group of proteins was down-regulated in AC-T-10%P when compared to normal AC-T. Examining the relationship of photosynthesis and toxin content of AC-T upon continuous photoperiod experiment revealed that while growth and associated toxin content increased after 8 days of continuous light, toxin content maintained constant when cells were shifted from continuous light to continuous dark for 3 days. This emphasized the cruciality of light availability on toxin biosynthesis in AC-T, while another light-independent mechanism may be responsible for higher toxicity in AC-T-10%P compared to normal AC-T. Taken all together, it is believed that the interplay between “illumination”, “photosynthesis”, “phosphate availability”, and “toxin production” is much more complicated than what we had previously anticipated. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Toxins, 2020, v. 12, no. 8, 477 | en_US |
dcterms.isPartOf | Toxins | en_US |
dcterms.issued | 2020 | - |
dc.identifier.scopus | 2-s2.0-85088852847 | - |
dc.identifier.pmid | 32727048 | - |
dc.identifier.eissn | 2072-6651 | en_US |
dc.identifier.artn | 477 | en_US |
dc.description.validate | 202010 bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS, a1487 | en_US |
dc.identifier.SubFormID | 45133 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Tse_Production_Paralytic_Shellfish.pdf | 5.49 MB | Adobe PDF | View/Open |
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