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http://hdl.handle.net/10397/88335
Title: | Regression of plaque enhancement within symptomatic middle cerebral artery atherosclerosis : a high-resolution MRI study | Authors: | Yang, WJ Abrigo, J Soo, YOY Wong, S Wong, KS Leung, TWH Chu, WCW Chen, XY |
Issue Date: | 2020 | Source: | Frontiers in neurology, 2020, v. 11, 755 | Abstract: | Objective: Contrast enhancement is a vital feature of the intracranial atherosclerotic plaque on high-resolution magnetic resonance imaging (HRMRI), but its clinical significance is still unclear. We aimed to quantitatively assess plaque enhancement patterns in the middle cerebral artery (MCA) atherosclerotic plaque. Methods: We conducted a cross-sectional study by prospectively recruiting stroke or transient ischemic attack patients with >30% of MCA stenosis of either side. All patients underwent contrast-enhanced HRMRI scans. Enrolled patients were classified into acute phase (<4 weeks), subacute phase (4–12 weeks) and chronic phase (>12 weeks) groups based on the time interval from stroke onset to imaging scan. Plaque enhancement index was calculated for each MCA lesion at the maximal narrowing site. Results: We identified a total of 89 MCA plaques [53 (60%) symptomatic and 36 (40%) asymptomatic; 57 (64%) acute, 18 (20%) subacute and 14 (16%) chronic] in 58 patients on HRMRI. Among the acute lesions, symptomatic plaques had a significantly stronger plaque enhancement than asymptomatic plaques (symptomatic vs. asymptomatic: 38.9 ± 18.2 vs. 18.2 ± 16.2, p < 0.001). Among the symptomatic lesions, plaque enhancement diminished with increasing time after stroke onset (38.9 ± 18.2, 22.0 ± 22.8, and 5.0 ± 10.1 for acute, subacute, and chronic phase, respectively; p = 0.001). Conclusion: Plaque enhancement in the acute atherosclerotic plaque is closely related to recent ischemic events. In symptomatic atherosclerosis, plaque enhancement regresses over time after ischemic stroke, which may offer the potential to monitor the plaque activity in intracranial atherosclerosis using HRMRI. |
Keywords: | Inflammation Intracranial atherosclerosis Magnetic resonance imaging Middle cerebral artery Plaque enhancement Stroke |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in neurology | EISSN: | 1664-2295 | DOI: | 10.3389/fneur.2020.00755 | Rights: | Copyright © 2020 Yang, Abrigo, Soo, Wong, Wong, Leung, Chu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Yang W-J, Abrigo J, Soo YO-Y, Wong S, Wong K-S, Leung TW-H, Chu WC-W and Chen X-Y (2020) Regression of Plaque Enhancement Within Symptomatic Middle Cerebral Artery Atherosclerosis: A High-Resolution MRI Study. Front. Neurol. 11:755, is available at https://doi.org/10.3389/fneur.2020.00755 |
Appears in Collections: | Journal/Magazine Article |
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