Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/8828
Title: Silk fibroin-based nanoparticles for drug delivery
Authors: Zhao, Z
Li, Y 
Xie, MB
Issue Date: 2015
Source: International journal of molecular sciences, Mar. 2015, v. 16, no. 3, p. 4880-4903
Abstract: Silk fibroin (SF) is a protein-based biomacromolecule with excellent biocompatibility, biodegradability and low immunogenicity. The development of SF-based nanoparticles for drug delivery have received considerable attention due to high binding capacity for various drugs, controlled drug release properties and mild preparation conditions. By adjusting the particle size, the chemical structure and properties, the modified or recombinant SF-based nanoparticles can be designed to improve the therapeutic efficiency of drugs encapsulated into these nanoparticles. Therefore, they can be used to deliver small molecule drugs (e.g., anti-cancer drugs), protein and growth factor drugs, gene drugs, etc. This paper reviews recent progress on SF-based nanoparticles, including chemical structure, properties, and preparation methods. In addition, the applications of SF-based nanoparticles as carriers for therapeutic drugs are also reviewed.
Keywords: Drug delivery
Nanoparticles
Preparation methods
Silk fibroin
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: International journal of molecular sciences 
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms16034880
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
The following publication Zhao, Z., Li, Y., & Xie, M. B. (2015). Silk fibroin-based nanoparticles for drug delivery. International Journal of Molecular Sciences, 16(3), (Suppl. ), 4880-4903 is available athttps://dx.doi.org/10.3390/ijms16034880
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