Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88112
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Mao, XW | - |
dc.creator | Tey, SK | - |
dc.creator | Yeung, CLS | - |
dc.creator | Kwong, EML | - |
dc.creator | Fung, YME | - |
dc.creator | Chung, CYS | - |
dc.creator | Mak, LY | - |
dc.creator | Wong, DKH | - |
dc.creator | Yuen, MF | - |
dc.creator | Ho, JCM | - |
dc.creator | Pang, H | - |
dc.creator | Wong, MP | - |
dc.creator | Leung, CON | - |
dc.creator | Lee, TKW | - |
dc.creator | Ma, V | - |
dc.creator | Cho, WCS | - |
dc.creator | Cao, PH | - |
dc.creator | Xu, XP | - |
dc.creator | Gao, Y | - |
dc.creator | Yam, JWP | - |
dc.date.accessioned | 2020-09-18T02:12:51Z | - |
dc.date.available | 2020-09-18T02:12:51Z | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10397/88112 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-VCH | en_US |
dc.rights | © 2020 The Authors. Published by Wiley‐VCH GmbH | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Mao, X. W., Tey, S. K., Yeung, C. L. S., Kwong, E. M. L., Fung, Y. M. E., Chung, C. Y. S., . . . Yam, J. W. P. (2020). Nidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary fibroblasts to secrete tumor necrosis factor receptor 1. Advanced Science, 1-14 is available at https://dx.doi.org/10.1002/advs.202002157 | en_US |
dc.subject | Extracellular vesicles | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Nidogen 1 | en_US |
dc.subject | Pre-metastatic niche | en_US |
dc.subject | Tumor necrosis factor receptor 1 | en_US |
dc.title | Nidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary fibroblasts to secrete tumor necrosis factor receptor 1 | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 14 | - |
dc.identifier.doi | 10.1002/advs.202002157 | - |
dcterms.abstract | In hepatocellular carcinoma (HCC) patients with extrahepatic metastasis, the lung is the most frequent site of metastasis. However, how the lung microenvironment favors disseminated cells remains unclear. Here, it is found that nidogen 1 (NID1) in metastatic HCC cell-derived extracellular vesicles (EVs) promotes pre-metastatic niche formation in the lung by enhancing angiogenesis and pulmonary endothelial permeability to facilitate colonization of tumor cells and extrahepatic metastasis. EV-NID1 also activates fibroblasts, which secrete tumor necrosis factor receptor 1 (TNFR1), facilitate lung colonization of tumor cells, and augment HCC cell growth and motility. Administration of anti-TNFR1 antibody effectively diminishes lung metastasis induced by the metastatic HCC cell-derived EVs in mice. In the clinical perspective, analysis of serum EV-NID1 and TNFR1 in HCC patients reveals their positive correlation and association with tumor stages suggesting the potential of these molecules as noninvasive biomarkers for the early detection of HCC. In conclusion, these results demonstrate the interplay of HCC EVs and activated fibroblasts in pre-metastatic niche formation and how blockage of their functions inhibits distant metastasis to the lungs. This study offers promise for the new direction of HCC treatment by targeting oncogenic EV components and their mediated pathways. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Advanced science, 2020, p. 1-14 | - |
dcterms.isPartOf | Advanced science | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000560680200001 | - |
dc.identifier.scopus | 2-s2.0-85089533361 | - |
dc.description.validate | 202009 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Mao_Nidogen_1-Enriched_Extracellular.pdf | 7.33 MB | Adobe PDF | View/Open |
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