Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88095
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Lai, WF | - |
dc.creator | Wong, WT | - |
dc.date.accessioned | 2020-09-18T02:12:41Z | - |
dc.date.available | 2020-09-18T02:12:41Z | - |
dc.identifier.issn | 1474-9718 | - |
dc.identifier.uri | http://hdl.handle.net/10397/88095 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | © 2020 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Lai, W. F., & Wong, W. T. (2020). Progress and trends in the development of therapies for hutchinson-gilford progeria syndrome. Aging Cell, 19(7), 1-17 is available at https://dx.doi.org/10.1111/acel.13175 | en_US |
dc.subject | Hutchinson-Gilford progeria syndrome | en_US |
dc.subject | Laminopathy | en_US |
dc.subject | Premature aging | en_US |
dc.subject | Treatment | en_US |
dc.title | Progress and trends in the development of therapies for hutchinson-gilford progeria syndrome | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 17 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 7 | - |
dc.identifier.doi | 10.1111/acel.13175 | - |
dcterms.abstract | Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic disease that leads to accelerated aging and often premature death caused by cardiovascular complications. Till now clinical management of HGPS has largely relied on the treatment of manifestations and on the prevention of secondary complications, cure for the disease has not yet been established. Addressing this need cannot only benefit progeria patients but may also provide insights into intervention design for combating physiological aging. By using the systematic review approach, this article revisits the overall progress in the development of strategies for HGPS treatment over the last ten years, from 2010 to 2019. In total, 1,906 articles have been retrieved, of which 56 studies have been included for further analysis. Based on the articles analyzed, the trends in the use of different HGPS models, along with the prevalence, efficiency, and limitations of different reported treatment strategies, have been examined. Emerging strategies for preclinical studies, and possible targets for intervention development, have also been presented as avenues for future research. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Aging cell, July 2020, v. 19, no. 7, e13175, p. 1-17 | - |
dcterms.isPartOf | Aging cell | - |
dcterms.issued | 2020-07 | - |
dc.identifier.isi | WOS:000544243900001 | - |
dc.identifier.scopus | 2-s2.0-85087182032 | - |
dc.identifier.pmid | 32596971 | - |
dc.identifier.eissn | 1474-9726 | - |
dc.identifier.artn | e13175 | - |
dc.description.validate | 202009 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Lai_Hutchinson-Gilford_Progeria_Syndrome.pdf | 759.72 kB | Adobe PDF | View/Open |
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