Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/88082
Title: | Miniaturized water-jet ultrasound indentation system for quantitative assessment of articular cartilage degeneration : a validation study | Authors: | Huang, YP Zheng, YP |
Issue Date: | 16-Jul-2020 | Source: | BioMed research international, 16 July 2020, v. 2020, 2316369, p. 1-13 | Abstract: | Osteoarthritis is a common joint disease affecting a large population especially the elderly where cartilage degeneration is one of its hallmark symptoms. There is a need to develop new devices and instruments for the early detection and treatment of cartilage degeneration. In this study, we describe the development of a miniaturized water-jet ultrasound indentation probe for this purpose. To evaluate the system, we applied it to characterize the degeneration of articular cartilage with the measurement of its morphologic, acoustic, and mechanical properties, using the enzymatic digestions of cartilage as a model of OA. Fifty cartilage samples were tested with 10 of them used for the reproducibility study and the other 40 for collagenase and trypsin digestions. Thickness, integrated reflection coefficient (IRC), effective stiffness, and energy dissipation ratio (EDR) were used to quantify the change of articular cartilage before and after degeneration. The measurement reproducibility as represented by the standardized coefficient of variation (SCV) was 2.6%, 10.2%, 11.5%, and 12.8% for thickness, IRC, stiffness, and EDR, respectively. A significant change of IRC, stiffness, and EDR was detected after degeneration by the designed probe (p<0.05). There was also a significant difference of IRC, stiffness, and EDR between trypsin and collagenase digestions (p<0.001). In conclusion, a miniaturized water-jet ultrasound indentation probe has been designed, which has been successfully used to detect and differentiate cartilage degeneration simulated by enzymatic digestions. This probe, with future development, can be potentially suitable for quantitative assessment of cartilage degeneration with an arthroscopic operation. | Publisher: | Hindawi Publishing Corporation | Journal: | BioMed research international | ISSN: | 2314-6133 | EISSN: | 2314-6141 | DOI: | 10.1155/2020/2316369 | Rights: | Copyright © 2020 Yan-Ping Huang and Yong-Ping Zheng. This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The following publication Huang, Y. P., & Zheng, Y. P. (2020). Miniaturized water-jet ultrasound indentation system for quantitative assessment of articular cartilage degeneration: A validation study. Biomed Research International, 2020, 1-13 is available at https://dx.doi.org/10.1155/2020/2316369 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Huang_Miniaturized_Water-Jet_Ultrasound.pdf | 1.71 MB | Adobe PDF | View/Open |
Page views
67
Last Week
0
0
Last month
Citations as of May 5, 2024
Downloads
47
Citations as of May 5, 2024
SCOPUSTM
Citations
2
Citations as of Apr 4, 2024
WEB OF SCIENCETM
Citations
1
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.