Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87939
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Xu, S | en_US |
dc.creator | Xie, F | en_US |
dc.creator | Tian, L | en_US |
dc.creator | Fallah, S | en_US |
dc.creator | Babaei, F | en_US |
dc.creator | Manno, SHC | en_US |
dc.creator | Manno, FAM | en_US |
dc.creator | III | en_US |
dc.creator | Zhu, L | en_US |
dc.creator | Wong, KF | en_US |
dc.creator | Liang, Y | en_US |
dc.creator | Ramalingam, R | en_US |
dc.creator | Sun, L | en_US |
dc.creator | Wang, X | en_US |
dc.creator | Plumb, R | en_US |
dc.creator | Gethings, L | en_US |
dc.creator | Lam, YW | en_US |
dc.creator | Cheng, SH | en_US |
dc.date.accessioned | 2020-09-04T00:52:59Z | - |
dc.date.available | 2020-09-04T00:52:59Z | - |
dc.identifier.issn | 0022-0795 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/87939 | - |
dc.language.iso | en | en_US |
dc.publisher | BioScientifica Ltd. | en_US |
dc.rights | © 2020 The Authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Xu, S., Xie, F., Tian, Li., Fallah, S., Babaei, F., Manno, S., Manno, F., Zhu, L., Wong, K., Liang, Y., Ramalingam, R., Sun, L., Wang, X., Plumb, R., Gethings, L., Lam, Y., & Cheng, S. (2020). Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish, Journal of Endocrinology, 245(1), 39-51, is available at https://joe.bioscientifica.com/view/journals/joe/245/1/JOE-19-0413.xml | en_US |
dc.subject | Estrogen | en_US |
dc.subject | Estrogen receptor | en_US |
dc.subject | Heart regeneration | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Sexually dimorphic | en_US |
dc.title | Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 39 | en_US |
dc.identifier.epage | 51 | en_US |
dc.identifier.volume | 245 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.doi | 10.1530/JOE-19-0413 | en_US |
dcterms.abstract | Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but the underlying mechanisms are not clear. Here, we found that zebrafish heart regeneration is faster in females, can be accelerated by estrogen and is suppressed by the estrogen-antagonist tamoxifen. Injuries to the zebrafish heart, but not other tissues, increased plasma estrogen levels and the expression of estrogen receptors, especially esr2a. The resulting endocrine disruption induces the expression of the female-specific protein vitellogenin in male zebrafish. Transcriptomic analyses suggested heart injuries triggered pronounced immune and inflammatory responses in females. These responses, previously shown to elicit heart regeneration, could be enhanced by estrogen treatment in males and reduced by tamoxifen in females. Furthermore, a prior exposure to estrogen preconditioned the zebrafish heart for an accelerated regeneration. Altogether, this study reveals that heart regeneration is modulated by an estrogen-inducible inflammatory response to cardiac injury. These findings elucidate a previously unknown layer of control in zebrafish heart regeneration and provide a new model system for the study of sexual differences in human cardiac repair. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of endocrinology, 2020, v. 245, no. 1, p.39-51 | en_US |
dcterms.isPartOf | Journal of endocrinology | en_US |
dcterms.issued | 2020 | - |
dc.identifier.scopus | 2-s2.0-85081386967 | - |
dc.identifier.pmid | 31977314 | - |
dc.identifier.eissn | 1479-6805 | en_US |
dc.description.validate | 202009 bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS, a1632 | - |
dc.identifier.SubFormID | 45680 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Xu_Estrogen_accelerates_heart.pdf | 4.8 MB | Adobe PDF | View/Open |
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