Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87934
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Computing | - |
dc.creator | Yi, HC | - |
dc.creator | You, ZH | - |
dc.creator | Huang, DS | - |
dc.creator | Guo, ZH | - |
dc.creator | Chan, KCC | - |
dc.creator | Li, Y | - |
dc.date.accessioned | 2020-09-04T00:52:56Z | - |
dc.date.available | 2020-09-04T00:52:56Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87934 | - |
dc.language.iso | en | en_US |
dc.publisher | Cell Press | en_US |
dc.rights | © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Yi, H. C., You, Z. H., Huang, D. S., Guo, Z. H., Chan, K. C., & Li, Y. (2020). Learning Representations to Predict Intermolecular Interactions on Large-Scale Heterogeneous Molecular Association Network. Iscience, 23(7), is available at https://doi.org/10.1016/j.isci.2020.101261 | en_US |
dc.subject | Biocomputational method | en_US |
dc.subject | Bioinformatics | en_US |
dc.subject | Computational bioinformatics | en_US |
dc.title | Learning representations to predict intermolecular interactions on large-scale heterogeneous molecular association network | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 23 | - |
dc.identifier.issue | 7 | - |
dc.identifier.doi | 10.1016/j.isci.2020.101261 | - |
dcterms.abstract | Molecular components that are functionally interdependent in human cells constitute molecular association networks. Disease can be caused by disturbance of multiple molecular interactions. New biomolecular regulatory mechanisms can be revealed by discovering new biomolecular interactions. To this end, a heterogeneous molecular association network is formed by systematically integrating comprehensive associations between miRNAs, lncRNAs, circRNAs, mRNAs, proteins, drugs, microbes, and complex diseases. We propose a machine learning method for predicting intermolecular interactions, named MMI-Pred. More specifically, a network embedding model is developed to fully exploit the network behavior of biomolecules, and attribute features are also calculated. Then, these discriminative features are combined to train a random forest classifier to predict intermolecular interactions. MMI-Pred achieves an outstanding performance of 93.50% accuracy in hybrid associations prediction under 5-fold cross-validation. This work provides systematic landscape and machine learning method to model and infer complex associations between various biological components. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | iScience, 2020, v. 23, no. 7, 101261 | - |
dcterms.isPartOf | iScience | - |
dcterms.issued | 2020 | - |
dc.identifier.scopus | 2-s2.0-85086566593 | - |
dc.identifier.eissn | 2589-0042 | - |
dc.identifier.artn | 101261 | - |
dc.description.validate | 202009 bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Yi_Learning_representations_predict.pdf | 2.76 MB | Adobe PDF | View/Open |
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