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Title: | Remineralising dentine caries using sodium fluoride with silver nanoparticles : an in vitro study | Authors: | Zhao, ISP Yin, IXX Mei, ML Lo, ECM Tang, JY Li, QL So, LY Chu, CH |
Issue Date: | 23-Apr-2020 | Source: | International journal of nanomedicine, 23 Apr. 2020, v. 15, p. 2829-2839 | Abstract: | Objective: To investigate the remineralizing and staining effects of sodium fluoride (NaF) solution with polyethylene glycol-coated silver nanoparticles (PEG-AgNPs) on artificial dentine caries. Materials and Methods: Demineralized human dentine blocks were allocated to three groups. The blocks in group 1 underwent a topical application of a 12% silver diamine fluoride (SDF, 14,150 ppm fluoride) solution. The blocks in group 2 received a topical application of a 2.5% NaF (11,310 ppm fluoride) with PEG-AgNPs (400 ppm silver). The blocks in group 3 received deionized water. All blocks were subjected to pH cycling for 8 days. The surface morphology and cross-sectional features were investigated using scanning electron microscopy (SEM). The color parameters, crystal characteristics, lesion depth, and collagen degradation of the blocks were assessed using digital spectrophotometry, X-ray diffraction (XRD), microcomputed tomography, and spectrophotometry with a hydroxyproline assay, respectively. Results: The SEM showed that dentine collagen was exposed in group 3 but not in groups 1 and 2. The mean lesion depths in groups 1 to 3 were 118 +/- 7 mu m, 121 +/- 14 mu m, and 339 +/- 20 mu m, respectively (groups1,2<3; p<0.001). The data indicated that fluoridated PEG-AgNPs introduced no significant color effect on dentine, but SDF caused distinct discoloration. The XRD indicated that silver chloride was formed in group 1, and fluorapatite was detected in groups 1 and 2. The concentration of hydroxyproline liberated from collagen was significantly less in groups 1 and 2 than in group 3. Conclusion: The use of NaF solution with PEG-AgNPs can remineralize artificial dentine caries and inhibit collagen degradation without causing significant tooth staining. |
Keywords: | Silver Nanoparticles Fluoride Dentine Caries Remineralization |
Publisher: | Dove Medical Press | Journal: | International journal of nanomedicine | ISSN: | 1176-9114 | EISSN: | 1178-2013 | DOI: | 10.2147/IJN.S247550 | Rights: | © 2020 Zhao et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). The following publication Zhao IS, Yin IX, Mei ML, Lo ECM, Tang J, Li Q, So LY, Chu CH. Remineralising Dentine Caries Using Sodium Fluoride with Silver Nanoparticles: An In Vitro Study. Int J Nanomedicine. 2020;15:2829-2839 is available at https://dx.doi.org/10.2147/IJN.S247550 |
Appears in Collections: | Journal/Magazine Article |
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