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Title: | Synthesis and characterization of fluoridated silver nanoparticles and their potential as a non-staining anti-caries agent | Authors: | Yin, IX Zhao, IS Mei, ML Lo, ECM Tang, J Li, Q So, LY Chu, CH |
Issue Date: | 6-May-2020 | Source: | International journal of nanomedicine, 6 May 2020, v. 15, p. 3207-3215 | Abstract: | Objectives: The first objective of this study was to prepare sodium fluoride (NaF) solution with various concentrations of polyethylene glycol-coated silver nanoparticles (PEG-AgNPs). The second objective was to study the antibacterial activity against Streptococcus mutans and the tooth-staining effect of the solution. Methods: PEG-AgNPs were prepared via the one-step chemical reduction of silver acetate with thiolated polyethylene glycol. The PEG-AgNPs were characterized with ultraviolet-visible spectrometry and transmission electron microscopy. The half maximal inhibitory concentration (IC50) for the PEG-AgNPs against Streptococcus mutans and human gingival fibroblasts (HGF-1) were determined. The staining effect on dentin and enamel for the 2.5% NaF solutions with PEG-AgNPs at 12,800, 6400, 1600, and 400 ppm was investigated using digital spectrophotometry. The IC50 of the fluoridated silver nanoparticles against Streptococcus mutans were measured. Results: The PEG-AgNPs have an average diameter of 2.56 +/- 0.43 nm and showed excellent stability at high ionic strength (2.5% NaF) for 18 months. The IC50 of PEG-AgNPs against Streptococcus mutans was found to be 21.16 +/- 1.08 ppm silver, which was half of IC50 against HGF-1 cells (42.36 +/- 1.12 ppm), providing a working range to kill bacteria with no harm to human cells. The formulations with different concentrations of PEG-AgNPs showed no significant staining of teeth. Combining PEG-AgNPs with NaF significantly expanded the therapeutic window against Streptococcus mutans by reducing its IC50. Conclusion: A biocompatible solution of NaF with PEG-AgNPs was developed. Because it has antibacterial activity against Streptococcus mutans and no tooth-staining effect, it can be used as an anti-caries agent. |
Keywords: | Silver Nanoparticles Fluoride Dentin Caries Antibacterial |
Publisher: | Dove Medical Press | Journal: | International journal of nanomedicine | ISSN: | 1176-9114 | EISSN: | 1178-2013 | DOI: | 10.2147/IJN.S243202 | Rights: | © 2020 Yin et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). The following publication Yin IX, Zhao IS, Mei ML, Lo ECM, Tang J, Li Q, So LY, Chu CH. Synthesis and Characterization of Fluoridated Silver Nanoparticles and Their Potential as a Non-Staining Anti-Caries Agent. Int J Nanomedicine. 2020;15:3207-3215 is available at https://dx.doi.org/10.2147/IJN.S243202 |
Appears in Collections: | Journal/Magazine Article |
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