Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87841
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Yang, Y | en_US |
dc.creator | Gao, P | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Tu, QF | en_US |
dc.creator | Bai, L | en_US |
dc.creator | Xiong, KQ | en_US |
dc.creator | Qiu, H | en_US |
dc.creator | Zhao, X | en_US |
dc.creator | Maitz, MF | en_US |
dc.creator | Wang, HY | en_US |
dc.creator | Li, XY | en_US |
dc.creator | Zhao, Q | en_US |
dc.creator | Xiao, Y | en_US |
dc.creator | Huang, N | en_US |
dc.creator | Yang, ZL | en_US |
dc.date.accessioned | 2020-08-19T06:27:41Z | - |
dc.date.available | 2020-08-19T06:27:41Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87841 | - |
dc.language.iso | en | en_US |
dc.publisher | American Association for the Advancement of Science | en_US |
dc.rights | Copyright © 2020 Ying Yang et al. Exclusive Licensee Science and Technology Review Publishing House. Distributed under a Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Ying Yang, Peng Gao, Juan Wang, Qiufen Tu, Long Bai, Kaiqin Xiong, Hua Qiu, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Xiangyang Li, Qiang Zhao, Yin Xiao, Nan Huang, Zhilu Yang, "Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy", Research, vol. 2020, Article ID 9203906, 20 pages, 2020 is available at https://dx.doi.org/10.34133/2020/9203906 | en_US |
dc.title | Endothelium-mimicking multifunctional coating modified cardiovascular stents via a stepwise metal-catechol-(Amine) surface engineering strategy | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 20 | en_US |
dc.identifier.volume | 2020 | en_US |
dc.identifier.doi | 10.34133/2020/9203906 | en_US |
dcterms.abstract | Stenting is currently the major therapeutic treatment for cardiovascular diseases. However, the nonbiogenic metal stents are inclined to trigger a cascade of cellular and molecular events including inflammatory response, thrombogenic reactions, smooth muscle cell hyperproliferation accompanied by the delayed arterial healing, and poor reendothelialization, thus leading to restenosis along with late stent thrombosis. To address prevalence critical problems, we present an endothelium-mimicking coating capable of rapid regeneration of a competently functioning new endothelial layer on stents through a stepwise metal (copper)-catechol-(amine) (MCA) surface chemistry strategy, leading to combinatorial endothelium-like functions with glutathione peroxidase-like catalytic activity and surface heparinization. Apart from the stable nitric oxide (NO) generating rate at the physiological level (2.2 x 10(-10) mol/cm(2)/min lasting for 60 days), this proposed strategy could also generate abundant amine groups for allowing a high heparin conjugation efficacy up to similar to 1 mu g/cm(2), which is considerably higher than most of the conventional heparinized surfaces. The resultant coating could create an ideal microenvironment for bringing in enhanced antithrombogenicity, anti-inflammation, anti-proliferation of smooth muscle cells, re-endothelialization by regulating relevant gene expressions, hence preventing restenosis in vivo. We envision that the stepwise MCA coating strategy would facilitate the surface endothelium-mimicking engineering of vascular stents and be therefore helpful in the clinic to reduce complications associated with stenosis. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Research, 2020, v. 2020, 9203906, p. 1-20 | en_US |
dcterms.isPartOf | Research | en_US |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000529342800001 | - |
dc.identifier.scopus | 2-s2.0-85087458212 | - |
dc.identifier.pmid | 32405627 | - |
dc.identifier.eissn | 2639-5274 | en_US |
dc.identifier.artn | 9203906 | en_US |
dc.description.validate | 202008 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0596-n19, OA_Scopus/WOS | en_US |
dc.identifier.SubFormID | 437 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Yang_Endothelium-Mimicking_Multifunctional_Coating.pdf | 4.38 MB | Adobe PDF | View/Open |
Page views
158
Last Week
0
0
Last month
Citations as of May 5, 2024
Downloads
12
Citations as of May 5, 2024
SCOPUSTM
Citations
101
Citations as of May 9, 2024
WEB OF SCIENCETM
Citations
100
Citations as of May 9, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.