Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87810
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Peng, L | - |
dc.creator | Zeng, LT | - |
dc.creator | Jin, HW | - |
dc.creator | Yang, LX | - |
dc.creator | Xiao, Y | - |
dc.creator | Lan, ZQ | - |
dc.creator | Yu, ZP | - |
dc.creator | Ouyang, S | - |
dc.creator | Zhang, LR | - |
dc.creator | Sun, N | - |
dc.date.accessioned | 2020-08-19T06:27:20Z | - |
dc.date.available | 2020-08-19T06:27:20Z | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.uri | http://hdl.handle.net/10397/87810 | - |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.rights | © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | en_US |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights | The following publication Liang Peng, Liting Zeng, Hongwei Jin, Lixin Yang, Yi Xiao, Ziquan Lan, Zhanpeng Yu, Shi Ouyang, Liangren Zhang & Ning Sun (2020) Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli, Journal of Enzyme Inhibition and Medicinal Chemistry, 35:1, 1224-1232 is available at https://dx.doi.org/10.1080/14756366.2020.1766453 | en_US |
dc.subject | Antibacterial | en_US |
dc.subject | Uropathogenic E | en_US |
dc.subject | Coli | en_US |
dc.subject | PPK1 | en_US |
dc.title | Discovery and antibacterial study of potential PPK1 inhibitors against uropathogenic E. coli | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1224 | - |
dc.identifier.epage | 1232 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 1 | - |
dc.identifier.doi | 10.1080/14756366.2020.1766453 | - |
dcterms.abstract | Novel antibacterial agents are urgently needed to address the infections caused by multi-drug resistant bacteria. Urinary tract infections are common infectious diseases in clinical. Most of these infections are caused by drug-resistant uropathogenic Escherichia coli. PPK1 is an essential kinase for bacterial motility, biofilm formation, quorum sensing, and virulence factors in the expression of uropathogenic E. coli. In the present study, two small molecules potentially targeting PPK1 were discovered through virtual screening and biological assays. The in vitro and in vivo results suggested that the interaction of these compounds with PPK1 can disrupt biofilm formation of uropathogenic E. coli and reduce invasive ability and resistance to oxidative stress of this strain. Moreover, the compounds exhibit good antibacterial bacterial activity in the mice with urinary tract infection. Taken together, our findings could provide a new chemotype for the development of antibacterials targeting PPK1. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of enzyme inhibition and medicinal chemistry, 2020, v. 35, no. 1, p. 1224-1232 | - |
dcterms.isPartOf | Journal of enzyme inhibition and medicinal chemistry | - |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000533474400001 | - |
dc.identifier.scopus | 2-s2.0-85084943722 | - |
dc.identifier.pmid | 32420773 | - |
dc.identifier.eissn | 1475-6374 | - |
dc.description.validate | 202008 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Peng_PPK1_E_Coli.pdf | 2.81 MB | Adobe PDF | View/Open |
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