Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87772
DC Field | Value | Language |
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dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Huang, JP | en_US |
dc.creator | van Zijl, PCM | en_US |
dc.creator | Han, XQ | en_US |
dc.creator | Dong, CM | en_US |
dc.creator | Cheng, GWY | en_US |
dc.creator | Tse, KH | en_US |
dc.creator | Knutsson, L | en_US |
dc.creator | Chen, L | en_US |
dc.creator | Lai, JHC | en_US |
dc.creator | Wu, EX | en_US |
dc.creator | Xu, JD | en_US |
dc.creator | Chan, KWY | en_US |
dc.date.accessioned | 2020-08-19T06:26:55Z | - |
dc.date.available | 2020-08-19T06:26:55Z | - |
dc.identifier.issn | 2375-2548 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/87772 | - |
dc.language.iso | en | en_US |
dc.publisher | American Association for the Advancement of Science | en_US |
dc.rights | Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC) (https://creativecommons.org/licenses/by-nc/4.0/). | en_US |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. | en_US |
dc.rights | The following publication J. Huang, P. C. M. van Zijl, X. Han, C. M. Dong, G. W. Y. Cheng, K.-H. Tse, L. Knutsson, L. Chen, J. H. C. Lai, E. X. Wu, J. Xu, K. W. Y. Chan, Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI. Sci. Adv. 6, eaba3884 (2020) is available at https://dx.doi.org/10.1126/sciadv.aba3884 | en_US |
dc.title | Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1 | en_US |
dc.identifier.epage | 9 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 20 | en_US |
dc.identifier.doi | 10.1126/sciadv.aba3884 | en_US |
dcterms.abstract | Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor D-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Science advances, 13 May 2020, v. 6, no. 20, eaba3884, p. 1-9 | en_US |
dcterms.isPartOf | Science advances | en_US |
dcterms.issued | 2020-05-13 | - |
dc.identifier.isi | WOS:000533573300043 | - |
dc.identifier.scopus | 2-s2.0-85084787075 | - |
dc.identifier.pmid | 32426510 | - |
dc.identifier.artn | eaba3884 | en_US |
dc.description.validate | 202008 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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Huang_Altered_D-Glucose_Brain.pdf | 5.06 MB | Adobe PDF | View/Open |
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