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http://hdl.handle.net/10397/87755
Title: | The acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats | Authors: | Cheung, KK Fung, TKH Mak, JCW Cheung, SY He, WJ Leung, JW Lau, BWM Ngai, SPC |
Issue Date: | 20-May-2020 | Source: | PLoS one, 2020, v. 15, no. 5, e0233523, p. 1-16 | Abstract: | Reduced exercise capacity is common in people with chronic obstructive pulmonary diseases (COPD) and chronic smokers and is suggested to be related to skeletal muscle dysfunction. Previous studies using human muscle biopsies have shown fiber-type shifting in chronic smokers particularly those with COPD. These results, however, are confounded with aging effects because people with COPD tend to be older. In the present study, we implemented an acute 7-day cigarette smoke-exposed model using Sprague-Dawley rats to evaluate early effects of cigarette smoking on soleus muscles. Rats (n = 5 per group) were randomly assigned to either a sham air (SA) or cigarette smoking (CS) groups of three different concentrations of total particulate matters (TPM) (CSTPM2.5, CSTPM5, CSTPM10). Significantly lower percentages of type I and higher type IIa fiber were detected in the soleus muscle in CS groups when compared with SA group. Of these, only CSTMP10 group exhibited significantly lower citrate synthase activity and higher muscle tumor necrosis factor-alpha level than that of SA group. Tumor necrosis factor-alpha level was correlated with the percentage of type I and IIa fibers. However, no significant between-group differences were found in fiber cross-sectional area, physical activities, or lung function assessments. In conclusion, acute smoking may directly trigger the onset of glycolytic fiber type shift in skeletal muscle independent of aging. | Publisher: | Public Library of Science | Journal: | PLoS one | EISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0233523 | Rights: | © 2020 Cheung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The following publication Cheung K-K, Fung TK-H, Mak JCW, Cheung S-Y, He W, Leung JW, et al. (2020) The acute effects of cigarette smoke exposure on muscle fiber type dynamics in rats. PLoS ONE 15(5): e0233523 is available at https://dx.doi.org/10.1371/journal.pone.0233523 |
Appears in Collections: | Journal/Magazine Article |
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