Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/87676
Title: Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin
Authors: Liu, ZH
Ge, RX
Zhou, JY
Yang, XZ
Cheng, KK 
Tao, JL
Wu, DL
Mao, J
Issue Date: 2020
Source: Oncogenesis, 14 Apr. 2020, v. 9, no. 4, 39, p. 1-12
Abstract: Enhanced migration is pivotal for the malignant development of glioblastoma (GBM), but the underlying molecular mechanism that modulates the migration of the GBM cells remains obscure. Here we show that nuclear factor IX (NFIX) is significantly upregulated in human GBM lesions compared with normal or low-grade gliomas. NFIX deficiency impairs the migration of GBM cells and inhibits the tumor growth in the hippocampus of immunodeficient nude mice. Mechanistically, NFIX silencing suppresses the expression of Ezrin, a protein that crosslinks actin cytoskeleton and plasma membrane, which is also positively correlated with GBM malignancy. NFIX depletion induced migration inhibition of GBM cells can be rescued by the replenishment of Ezrin. Furthermore, we identify a NFIX response element (RE) between -840 and -825 bp in the promoter region of the Ezrin gene. Altogether, our findings show, for the first time that NFIX can transcriptionally upregulate the expression of Ezrin and contribute to the enhanced migration of GBM cells, suggesting that NFIX is a potential target for GBM therapy.
Publisher: Nature Publishing Group
Journal: Oncogenesis 
EISSN: 2157-9024
DOI: 10.1038/s41389-020-0223-2
Rights: © The Author(s) 2020
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
The following publication Liu, Z., Ge, R., Zhou, J. et al. Nuclear factor IX promotes glioblastoma development through transcriptional activation of Ezrin. Oncogenesis 9, 39 (2020) is available at https://dx.doi.org/10.1038/s41389-020-0223-2
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