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Title: | Correlation of adventitial Vasa vasorum with intracranial atherosclerosis a postmortem study | Authors: | Zheng, L Yang, WJ Niu, CB Zhao, HL Wong, KS Leung, TWH Chen, XY |
Issue Date: | 2018 | Source: | Journal of stroke, Sept 2018, v. 20, no. 3, p. 342-349 | Abstract: | Background and Purpose Vasa vasorum (VV) have been believed to be rare or non-existent in small-caliber intracranial arteries. In a series of human cerebral artery specimens, we identified and examined the distribution of VV in association with co-existing intracranial atherosclerosis. Methods We obtained cerebral artery specimens from 32 consecutive autopsies of subjects aged 45 years or above. We scrutinized middle cerebral artery (MCA), vertebral artery (VA), and basilar artery (BA) for the presence of adventitial VV. We described the distribution of VV, and the characteristics of co-existing atherosclerotic lesions. Results Among 157 intracranial arteries, adventitial VV were present in 74 of the 157 specimens (47%), involving MCA (n=13, 18%), BA (n=14, 19%), and VA (n=47, 64%). Although qualitatively these 74 adventitial VV distributed similarly in arteries with or without atherosclerotic lesions (disease-free arteries n=4/8; arteries of pre-atherosclerosis n=17/42; and arteries of progressive atherosclerosis n=53/107), the presence of adventitial VV in intracranial VA was associated with a heavier plaque load (1.72 +/- 1.66 mm(2) vs. 0.40 +/- 0.32 mm(2), P<0.001), severer luminal stenosis (25%+/- 21% vs. 12%+/- 9%, P=0.002), higher rate of concentric lesions (79% vs. 36%, P=0.002), and denser intraplaque calcification (44% vs. 0%, P=0.003). Histologically, intracranial VA with VV had a larger diameter (3.40 +/- 0.79 mm vs. 2.34 +/- 0.58 mm, P<0.001), thicker arterial wall (0.31 +/- 0.13 mm vs. 0.23 +/- 0.06 mm, P=0.002), and a larger intima-media (0.19 +/- 0.09 mm vs. 0.13 +/- 0.04 mm, P=0.003) than VA without VV. Conclusions Our study demonstrated the distribution of adventitial VV within brain vasculature and association between vertebral VV and progressive atherosclerotic lesions with a heavier plaque load and denser intraplaque calcification. |
Keywords: | Atherosclerosis Angiogenesis Vasa vasorum |
Publisher: | Korean Stroke Society | Journal: | Journal of stroke | ISSN: | 2287-6391 | EISSN: | 2287-6405 | DOI: | 10.5853/jos.2018.01263 | Rights: | Copyright © 2018 Korean Stroke Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The following publication Zheng, L., Yang, W. J., Niu, C. B., Zhao, H. L., Wong, K. S., Leung, T. W. H., & Chen, X. Y. (2018). Correlation of adventitial Vasa vasorum with intracranial atherosclerosis a postmortem study. Journal of Spine, 20(3), 342-349 is available at https://dx.doi.org/10.5853/jos.2018.01263 |
Appears in Collections: | Journal/Magazine Article |
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