Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87554
DC Field | Value | Language |
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dc.contributor | Department of Biomedical Engineering | - |
dc.creator | Chan, ST | en_US |
dc.creator | Evans, KC | en_US |
dc.creator | Song, TY | en_US |
dc.creator | Selb, J | en_US |
dc.creator | Van Der Kouwe, A | en_US |
dc.creator | Rosen, BR | en_US |
dc.creator | Zheng, YP | en_US |
dc.creator | Ahn, A | en_US |
dc.creator | Kwong, KK | en_US |
dc.date.accessioned | 2020-07-16T03:58:17Z | - |
dc.date.available | 2020-07-16T03:58:17Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87554 | - |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2020 Chan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
dc.rights | The following publication Chan S-t, Evans KC, Song T-y, Selb J, van der Kouwe A, Rosen BR, et al. (2020) Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge. PLoS ONE 15(3): e0225915, is available at https://doi.org/10.1371/journal.pone.0225915 | en_US |
dc.title | Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0225915 | en_US |
dcterms.abstract | Background Hypercapnia during breath holding is believed to be the dominant driver behind the modulation of cerebral blood flow (CBF). However, increasing evidence show that mild hypoxia and mild hypercapnia in breath hold (BH) could work synergistically to enhance CBF response. We hypothesized that breath-by-breath O2-CO2 exchange ratio (bER), defined as the ratio of the change in partial pressure of oxygen ((ΔPO2) to that of carbon dioxide (ΔPCO2) between end inspiration and end expiration, would be able to better correlate with the global and regional cerebral hemodynamic responses (CHR) to BH challenge. We aimed to investigate whether bER is a more useful index than end-tidal PCO2 to characterize cerebrovascular reactivity (CVR) under BH challenge. | - |
dcterms.abstract | Methods We used transcranial Doppler ultrasound (TCD) to evaluate CHR under BH challenge by measuring cerebral blood flow velocity (CBFv) in the middle cerebral arteries. Regional changes in CHR to BH and exogenous CO2 challenges were mapped with blood oxygenation level dependent (BOLD) signal changes using functional magnetic resonance imaging (fMRI). We correlated respiratory gas exchange (RGE) metrics (bER, ΔPO2, ΔPCO2, endtidal PCO2 and PO2, and time of breaths) with CHR (CBFv and BOLD) to BH challenge. Temporal features and frequency characteristics of RGE metrics and their coherence with CHR were examined. | - |
dcterms.abstract | Results CHR to brief BH epochs and free breathing were coupled with both ΔPO2 and ΔPCO2. We found that bER was superior to either ΔPO2 or ΔPCO2 alone in coupling with the changes of CBFv and BOLD signals under breath hold challenge. The regional CVR results derived by regressing BOLD signal changes on bER under BH challenge resembled those derived by regressing BOLD signal changes on end-tidal PCO2 under exogenous CO2 challenge. | - |
dcterms.abstract | Conclusion Our findings provide a novel insight on the potential of using bER to better quantify CVR changes under BH challenge. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | PLoS one, 2020, v. 15, no. 3, e0225915 | en_US |
dcterms.isPartOf | PLoS one | en_US |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000535305100003 | - |
dc.identifier.scopus | 2-s2.0-85082134251 | - |
dc.identifier.pmid | 32208415 | - |
dc.identifier.eissn | 1932-6203 | en_US |
dc.identifier.artn | e0225915 | en_US |
dc.description.validate | 202007 bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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Chan_Cerebrovascular_reactivity_assessment.pdf | 2.33 MB | Adobe PDF | View/Open |
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