Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/87496
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Xu, S | en_US |
dc.creator | Zhang, H | en_US |
dc.creator | Pao, PC | en_US |
dc.creator | Lee, A | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Chan, YS | en_US |
dc.creator | Manno III, FAM | en_US |
dc.creator | Chan, SW | en_US |
dc.creator | Cheng, SH | en_US |
dc.creator | Chen, X | en_US |
dc.date.accessioned | 2020-07-16T03:57:32Z | - |
dc.date.available | 2020-07-16T03:57:32Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/87496 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | en_US |
dc.rights | The following publication Xu, S., Zhang, H., Pao, P. C., Lee, A., Wang, J., Chan, Y. S., ... & Chen, X. (2020). Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons. Aquatic Toxicology, 105469 is available at https://doi.org/10.1016/j.aquatox.2020.105469 | en_US |
dc.subject | Double-Strand DNA break | en_US |
dc.subject | Estrogen receptor | en_US |
dc.subject | Estrogenic activity | en_US |
dc.subject | Neurodevelopment | en_US |
dc.subject | Neurons | en_US |
dc.subject | Phthalates | en_US |
dc.subject | Zebrafish | en_US |
dc.title | Exposure to phthalates impaired neurodevelopment through estrogenic effects and induced DNA damage in neurons | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 222 | en_US |
dc.identifier.doi | 10.1016/j.aquatox.2020.105469 | en_US |
dcterms.abstract | Phthalates are commonly used in plastic products in daily life. The endocrine-disrupting effects of phthalates have been widely reported. Accumulating evidence from human cohorts and lab animals indicate exposure to phthalates might impair neurodevelopment. However, the direct causal relationship and mechanism between phthalates with neurodevelopment and neurotoxicity have not been firmly established. We found that phthalates (i.e. DBP, DINP, BBP) disrupted the expression of estrogen receptors (esr1, esr2a, esr2b), and impaired neurogenesis in the brain of zebrafish during embryonic development. Moreover, the abnormal expression of estrogen receptors, especially esr2a, was partly rescued in zebrafish which exposed to phthalates, with the estrogen receptor antagonist tamoxifen. Hence, impaired neurogenesis of zebrafish exposed to phthalates was partly reversed by tamoxifen treatment. Moreover, our results show that induced pluripotent stem cells (iPSC)-derived human neurons exposed to phthalates triggered double-strand DNA breaks in vitro. Overall, this study demonstrates that exposure to phthalates affects neurodevelopment in zebrafish embryos and induces neurotoxicity in human neurons partly through disrupting the expression of estrogen receptors. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Aquatic toxicology, 2020, v. 222, 105469 | en_US |
dcterms.isPartOf | Aquatic toxicology | en_US |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000528192300011 | - |
dc.identifier.scopus | 2-s2.0-85081387084 | - |
dc.identifier.eissn | 0166-445X | en_US |
dc.identifier.artn | 105469 | en_US |
dc.description.validate | 202007 bcma | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Xu_Exposure_phthalates_impaired.pdf | 1.61 MB | Adobe PDF | View/Open |
Page views
35
Last Week
0
0
Last month
Citations as of May 12, 2024
Downloads
28
Citations as of May 12, 2024
SCOPUSTM
Citations
43
Citations as of May 16, 2024
WEB OF SCIENCETM
Citations
42
Citations as of May 16, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.