Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/82205
Title: Biology of tendon stem cells and tendon in aging
Authors: Lui, PPY
Wong, CM 
Issue Date: 2020
Source: Frontiers in genetics, 16 Jan. 2020, v. 10, 1338, p. 1-14
Abstract: Both tendon injuries and tendinopathies, particularly rotator cuff tears, increase with tendon aging. Tendon stem cells play important roles in promoting tendon growth, maintenance, and repair. Aged tendons show a decline in regenerative potential coupled with a loss of stem cell function. Recent studies draw attention to aging primarily a disorder of stem cells. The micro-environment ("niche") where stem cells resided in vivo provides signals that direct them to metabolize, self-renew, differentiate, or remain quiescent. These signals include receptors and secreted soluble factors for cell-cell communication, extracellular matrix, oxidative stress, and vascularity. Both intrinsic cellular deficits and aged niche, coupled with age-associated systemic changes of hormonal and metabolic signals can inhibit or alter the functions of tendon stem cells, resulting in reduced fitness of these primitive cells and hence more frequent injuries and poor outcomes of tendon repair. This review aims to summarize the biological changes of aged tendons. The biological changes of tendon stem cells in aging are reviewed after a systematic search of the PubMed. Relevant factors of stem cell aging including cell-intrinsic factors, changes of microenvironment, and age-associated systemic changes of hormonal and metabolic signals are examined, with findings related to tendon stem cells highlighted when literature is available. Future research directions on the aging mechanisms of tendon stem cells are discussed. Better understanding of the molecular mechanisms underlying the functional decline of aged tendon stem cells would provide insight for the rational design of rejuvenating therapies.
Keywords: Tendon-derived stem cells
Tendon stem cells
Stem cell niche
Tendon aging
Stem cell aging
Publisher: Frontiers Research Foundation
Journal: Frontiers in genetics 
EISSN: 1664-8021
DOI: 10.3389/fgene.2019.01338
Rights: Copyright © 2020 Lui and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Lui PPY and Wong CM (2020) Biology of Tendon Stem Cells and Tendon in Aging. Front. Genet. 10:1338, 1-14 is available at https://dx.doi.org/10.3389/fgene.2019.01338
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