Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81889
Title: Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020 : a data-driven analysis in the early phase of the outbreak
Authors: Zhao, S
Lin, Q
Ran, J
Musa, SS 
Yang, G
Wang, W
Lou, Y 
Gao, D
Yang, L
He, D 
Wang, MH
Keywords: Basic reproduction number
Novel coronavirus (2019-nCoV)
Issue Date: 2020
Publisher: Elsevier
Source: International journal of infectious diseases, 2020, v. 92, p. 214-217 How to cite?
Journal: International journal of infectious diseases 
Abstract: Backgrounds: An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and other countries. We present estimates of the basic reproduction number, R0, of 2019-nCoV in the early phase of the outbreak.
Methods: Accounting for the impact of the variations in disease reporting rate, we modelled the epidemic curve of 2019-nCoV cases time series, in mainland China from January 10 to January 24, 2020, through the exponential growth. With the estimated intrinsic growth rate (γ), we estimated R0 by using the serial intervals (SI) of two other well-known coronavirus diseases, MERS and SARS, as approximations for the true unknown SI.
Findings: The early outbreak data largely follows the exponential growth. We estimated that the mean R0 ranges from 2.24 (95%CI: 1.96–2.55) to 3.58 (95%CI: 2.89–4.39) associated with 8-fold to 2-fold increase in the reporting rate. We demonstrated that changes in reporting rate substantially affect estimates of R0.
Conclusion: The mean estimate of R0 for the 2019-nCoV ranges from 2.24 to 3.58, and is significantly larger than 1. Our findings indicate the potential of 2019-nCoV to cause outbreaks.
URI: http://hdl.handle.net/10397/81889
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2020.01.050
Rights: © 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
The following publication Zhao, S., Lin, Q., Ran, J., Musa, S. S., Yang, G., Wang, W., ... & Wang, M. H. (2020). Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. International Journal of Infectious Diseases, 92, 214-217. is available at https://dx.doi.org/10.1016/j.ijid.2020.01.050
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