Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/81772
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | - |
dc.creator | Wang, YM | en_US |
dc.creator | Wu, D | en_US |
dc.creator | Wu, GH | en_US |
dc.creator | Wu, JG | en_US |
dc.creator | Lu, SM | en_US |
dc.creator | Lo, J | en_US |
dc.creator | He, Y | en_US |
dc.creator | Zhao, C | en_US |
dc.creator | Zhao, X | en_US |
dc.creator | Zhang, HB | en_US |
dc.date.accessioned | 2020-02-10T12:29:06Z | - |
dc.date.available | 2020-02-10T12:29:06Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/81772 | - |
dc.language.iso | en | en_US |
dc.publisher | Ivyspring International Publisher | en_US |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. | en_US |
dc.rights | The following publication Wang Y, Wu D, Wu G, Wu J, Lu S, Lo J, He Y, Zhao C, Zhao X, Zhang H, Wang S. Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy. Theranostics 2020; 10(1):300-311 is available at https://dx.doi.org/10.7150/thno.38736 | en_US |
dc.subject | Metastasis-on-a-chip | en_US |
dc.subject | Tumor progression | en_US |
dc.subject | Chemotherapy | en_US |
dc.subject | Drug delivery | en_US |
dc.title | Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 300 | en_US |
dc.identifier.epage | 311 | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.doi | 10.7150/thno.38736 | en_US |
dcterms.abstract | Metastasis is one of the most important factors that lead to poor prognosis in cancer patients, and effective suppression of the growth of primary cancer cells in a metastatic site is paramount in averting cancer progression. However, there is a lack of biomimetic three-dimensional (3D) in vitro models that can closely mimic the continuous growth of metastatic cancer cells in an organ-specific extracellular microenvironment (ECM) for assessing effective therapeutic strategies. | - |
dcterms.abstract | Methods: In this metastatic tumor progression model, kidney cancer cells (Caki-1) and hepatocytes (i.e., HepLL cells) were co-cultured at an increasing ratio from 1:9 to 9:1 in a decellularized liver matrix (DLM)/gelatin methacryloyl (GelMA)-based biomimetic liver microtissue in a microfluidic device. | - |
dcterms.abstract | Results: Via this model, we successfully demonstrated a linear anti-cancer relationship between the concentration of anti-cancer drug 5-Fluorouracil (5-FU) and the percentage of Caki-1 cells in the co-culture system (R-2 = 0.89). Furthermore, the Poly(lactide-co-glycolide) (PLGA)-poly(ethylene glycol) (PEG)-based delivery system showed superior efficacy to free 5-FU in killing Caki-1 cells. | - |
dcterms.abstract | Conclusions: In this study, we present a novel 3D metastasis-on-a-chip model mimicking the progression of kidney cancer cells metastasized to the liver for predicting treatment efficacy. Taken together, our study proved that the tumor progression model based on metastasis-on-a-chip with organ-specific ECM would provide a valuable tool for rapidly assessing treatment regimens and developing new chemotherapeutic agents. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Theranostics, 2020, v. 10, no. 1, p. 300-311 | en_US |
dcterms.isPartOf | Theranostics | en_US |
dcterms.issued | 2020 | - |
dc.identifier.isi | WOS:000497314800020 | - |
dc.identifier.scopus | 2-s2.0-85077479966 | - |
dc.identifier.eissn | 1838-7640 | en_US |
dc.description.validate | 202002 bcrc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Wang_Metastasis-on-a-chip_Mimicking_Progression.pdf | 2.14 MB | Adobe PDF | View/Open |
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