Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81772
DC FieldValueLanguage
dc.contributorDepartment of Biomedical Engineering-
dc.creatorWang, YM-
dc.creatorWu, D-
dc.creatorWu, GH-
dc.creatorWu, JG-
dc.creatorLu, SM-
dc.creatorLo, J-
dc.creatorHe, Y-
dc.creatorZhao, C-
dc.creatorZhao, X-
dc.creatorZhang, HB-
dc.date.accessioned2020-02-10T12:29:06Z-
dc.date.available2020-02-10T12:29:06Z-
dc.identifier.urihttp://hdl.handle.net/10397/81772-
dc.language.isoenen_US
dc.publisherIvyspring International Publisheren_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.en_US
dc.rightsThe following publication Wang Y, Wu D, Wu G, Wu J, Lu S, Lo J, He Y, Zhao C, Zhao X, Zhang H, Wang S. Metastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacy. Theranostics 2020; 10(1):300-311 is available at https://dx.doi.org/10.7150/thno.38736en_US
dc.subjectMetastasis-on-a-chipen_US
dc.subjectTumor progressionen_US
dc.subjectChemotherapyen_US
dc.subjectDrug deliveryen_US
dc.titleMetastasis-on-a-chip mimicking the progression of kidney cancer in the liver for predicting treatment efficacyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage300-
dc.identifier.epage311-
dc.identifier.volume10-
dc.identifier.issue1-
dc.identifier.doi10.7150/thno.38736-
dcterms.abstractMetastasis is one of the most important factors that lead to poor prognosis in cancer patients, and effective suppression of the growth of primary cancer cells in a metastatic site is paramount in averting cancer progression. However, there is a lack of biomimetic three-dimensional (3D) in vitro models that can closely mimic the continuous growth of metastatic cancer cells in an organ-specific extracellular microenvironment (ECM) for assessing effective therapeutic strategies.-
dcterms.abstractMethods: In this metastatic tumor progression model, kidney cancer cells (Caki-1) and hepatocytes (i.e., HepLL cells) were co-cultured at an increasing ratio from 1:9 to 9:1 in a decellularized liver matrix (DLM)/gelatin methacryloyl (GelMA)-based biomimetic liver microtissue in a microfluidic device.-
dcterms.abstractResults: Via this model, we successfully demonstrated a linear anti-cancer relationship between the concentration of anti-cancer drug 5-Fluorouracil (5-FU) and the percentage of Caki-1 cells in the co-culture system (R-2 = 0.89). Furthermore, the Poly(lactide-co-glycolide) (PLGA)-poly(ethylene glycol) (PEG)-based delivery system showed superior efficacy to free 5-FU in killing Caki-1 cells.-
dcterms.abstractConclusions: In this study, we present a novel 3D metastasis-on-a-chip model mimicking the progression of kidney cancer cells metastasized to the liver for predicting treatment efficacy. Taken together, our study proved that the tumor progression model based on metastasis-on-a-chip with organ-specific ECM would provide a valuable tool for rapidly assessing treatment regimens and developing new chemotherapeutic agents.-
dcterms.bibliographicCitationTheranostics, 2020, v. 10, no. 1, p. 300-311-
dcterms.isPartOfTheranostics-
dcterms.issued2020-
dc.identifier.isiWOS:000497314800020-
dc.identifier.eissn1838-7640-
dc.description.validate202002 bcrc-
dc.description.oapublished_final-
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