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Title: Leclercia adecarboxylata from human gut flora carries mcr-4.3 and bla(IMP-4)-bearing plasmids
Authors: Sun, QL
Wang, HY
Shu, LB
Dong, N 
Yang, F
Zhou, HW
Chen, S 
Zhang, R
Issue Date: 2019
Source: Frontiers in microbiology, 5 Dec. 2019, v. 10, 2805, p. 1-5
Abstract: A clinical Leclercia adecarboxylata strain harboring the mcr-4.3 and bla(IMP-4) genes was isolated from active rectal screening of carbapenem-resistant Enterobacteriaceae (CRE) in a patient. The isolate was found to harbor seven plasmids, including a 94,635 bp bla(IMP-4)-bearing IncN plasmid and a 9,782 bp mcr-4.3-bearing ColE10-type plasmid. The isolate was susceptible to colistin despite carrying the mcr-4.3 gene, suggesting that this MCR-4 variant may not be functional. Carriage of antibiotic resistance genes in human gut L. adecarboxylata strain suggests that close surveillance of resistance strains in the human gut flora should be included as a routine clinical practice to prevent occurrence of infections, especially among immunocompromised patients.
Keywords: Leclercia adecarboxylata
Gut flora
Carbapenem resistance
Publisher: Frontiers Research Foundation
Journal: Frontiers in microbiology 
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.02805
Rights: Copyright © 2019 Sun, Wang, Shu, Dong, Yang, Zhou, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ( The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Sun Q, Wang H, Shu L, Dong N, Yang F, Zhou H, Chen S and Zhang R (2019) Leclercia adecarboxylata From Human Gut Flora Carries mcr-4.3 and blaIMP-4-Bearing Plasmids. Front. Microbiol. 10:2805, 1-5 is available at
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