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Title: Chemodivergent synthesis of n-(pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines from alpha-bromoketones and 2-aminopyridines
Authors: Liu, YP
Lu, LX
Zhou, HP
Xu, FJ
Ma, C 
Huang, ZJ
Xu, JY
Xu, ST
Issue Date: 2019
Publisher: Royal Society of Chemistry
Source: RSC advances, 2019, v. 9, no. 59, p. 34671-34676 How to cite?
Journal: RSC advances 
Abstract: N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from alpha-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I-2 and TBHP and the reaction conditions were mild and metal-free. Whereas 3-bromoimidazopyridines were obtained in ethyl acetate via one-pot tandem cyclization/bromination when only TBHP was added, the cyclization to form imidazopyridines was promoted by the further bromination, no base was needed, and the versatile 3-bromoimidazopyridines could be further transferred to other skeletons.
EISSN: 2046-2069
DOI: 10.1039/c9ra06724h
Rights: This journal is © The Royal Society of Chemistry 2019
This article is licensed under a Creative Commons Attibution-NonCommercial 3.0 Unported Licence (
The following publication Liu, Y. P., Lu, L. X., Zhou, H. P., Xu, F. J., Ma, C., Huang, Z. J., . . . Xu, S. T. (2019). Chemodivergent synthesis of n-(pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines from alpha-bromoketones and 2-aminopyridines. RSC Advances, 9(59), 34671-34676 is available at
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