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Title: Increasing adiponergic system activity as a potential treatment for depressive disorders
Authors: Formolo, DA 
Lee, THY 
Yau, SY 
Keywords: Adiponectin
Adiponectin receptors
Issue Date: 2019
Publisher: Humana Press
Source: Molecular neurobiology, Dec. 2019, v. 56, no. 12, p. 7966-7976 How to cite?
Journal: Molecular neurobiology 
Abstract: Depression is the most devastating mental disorder and one of the leading contributors to the global medical burden. Current antidepressant prescriptions present drawbacks, including treatment resistance, delayed onset of treatment response, and side effects. The rapid and long-lasting antidepressant effect of ketamine has brought hope to treatment-resistant major depressive disorder patients. However, ketamine has undesirable addictive properties and is a drug of abuse. There is an urgent need, therefore, to develop novel pharmacological interventions that could be as effective as ketamine, but without its side effects. Adiponectin, a pleiotropic adipocyte-secreted hormone, has insulin-sensitizing and neurotrophic properties. It can cross the blood-brain barrier and target multiple brain regions where the adiponectin receptors are detected. Emerging evidence has suggested that adiponectin and the adiponectin receptor agonist, AdipoRon, could promote adult neurogenesis, dendritic and spine remodeling, and synaptic plasticity in the hippocampus, resulting in antidepressant effects in adult mice. By summarizing the most recent clinical and animal studies, this review provides a timely insight on how modulating the adiponergic system in the hippocampus could be a potential therapeutic target for an effective and fast-acting antidepressant response.
ISSN: 0893-7648
EISSN: 1559-1182
DOI: 10.1007/s12035-019-01644-3
Rights: © The Author(s) 2019
Open Access This article is distributed under the terms of the CreativeCommons Attribution 4.0 International License (, which permits unrestricted use,distribution, and reproductionin any medium, provided you giveappropriate credit to the original author(s) and the source, provide a linkto the Creative Commons license, and indicate if changes were made.
The following publication Formolo, D. A., Lee, T. H. Y., & Yau, S. Y. (2019). Increasing adiponergic system activity as a potential treatment for depressive disorders. Molecular neurobiology, 56(12), 7966-7976 is available at
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