Please use this identifier to cite or link to this item:
Title: Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers
Authors: Zhang, Y
Cheng, BCY 
Li, C
Tao, YH
Yu, CJ
Liu, XY
Gao, XY
Luo, G
Issue Date: 2019
Publisher: Royal Society of Chemistry
Source: RSC advances, 25 Sept. 2019, v. 9, no. 52, p. 30292-30301 How to cite?
Journal: RSC advances 
Abstract: Inhalation therapy is the first-line therapy for the treatment of respiratory diseases. Re-Du-Ning inhalation solution (RIS) is an aerosol derivative from the Re-Du-Ning injection and has been clinically used to treat respiratory diseases like pneumonia for more than twenty years in China. However, the aerosolization and inhalation performances of RIS using different nebulizers have not been characterized, which may affect the therapeutic effects of RIS on respiratory diseases. We investigated the inhalation performances of RIS using five different nebulizers utilizing Spraytec, breath simulator of BRS 2000 and NGI techniques. We tested 5 different types of jet nebulizer, using RIS and an adult breathing pattern, to determine the difference in aerosol delivery over time. The particle size distribution of RIS was monitored by a Spraytec laser particle sizer. Fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) for RIS were measured using NGI. Aerosol deposited on the filter was analysed using HPLC. Nebulization time was much longer for the Pari Boy SX (red) nebulizer than for the other nebulizers, with the minimum delivery rate (DR) and the maximum total delivered dose (TDD) and total exhalation dose (TED). Nebulization time for Pari Boy SX (blue) was the lowest, with the highest DR and the lowest TDD and TED. Furthermore, the aerodynamic particle size of RIS was much larger for the Pari blue and Pari LC Plus than other nebulizers. Pari red produced the smallest aerodynamic particle size of RIS in these five nebulizers. In addition, a good linear relationship was found between MMAD and D-50 in these five nebulizers. The results demonstrated that Pari Boy SX (red) delivered most slowly and produced the smallest aerodynamic particle size of the RIS aerosols, which may be applied to manage lower respiratory diseases. Moreover, Pari LC Plus and Pari Boy SX (blue) emitted quickly and generated larger aerodynamic particle size of RIS aerosols, which could be used to treat upper respiratory diseases. A good linear relationship between MMAD and D-50 showed Spraytec could be a reliable technique for the development, evaluation and quality control of aerosol particles of inhalation solution preparations.
EISSN: 2046-2069
DOI: 10.1039/c9ra06177k
Rights: This journal is © The Royal Society of Chemistry 2019
This article is licensed under a Creative Commons Attibution-NonCommercial 3.0 Unported Licence (https://Creative
The following publication Zhang, Y., Cheng, B. C. Y., Li, C., Tao, Y. H., Yu, C. J., Liu, X. Y., . . . Luo, G. (2019). Characterization and comparison of Re-Du-Ning aerosol particles generated by different jet nebulizers. RSC Advances, 9(52), 30292-30301 is available at
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Zhang_Re-Du-Ning_Aerosol_Particles.pdf871.99 kBAdobe PDFView/Open
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents


Citations as of May 15, 2020


Citations as of May 19, 2020

Page view(s)

Citations as of May 6, 2020


Citations as of May 6, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.