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Title: Association between long-term orthokeratology responses and corneal biomechanics
Authors: Lam, AKC 
Hon, Y 
Leung, SYY
ShuHo, L
Chong, J
Lam, DCC
Issue Date: 2019
Publisher: Nature Publishing Group
Source: Scientific reports, 2019, v. 9, no. 1, 12566 How to cite?
Journal: Data in brief 
Abstract: Myopia is very prevalent worldwide, especially among Asian populations. Orthokeratology is a proven intervention to reduce myopia progression. The current study investigated association between baseline corneal biomechanics and orthokeratology responses, and changes of corneal biomechanics from long-term orthokeratology. We fitted 59 adult subjects having myopia between −4.00D to −5.00D with overnight orthokeratology. Corneal biomechanics was measured through dynamic bidirectional corneal applanation (in terms of corneal hysteresis, CH and corneal resistance factor, CRF) and corneal indentation (in terms of corneal stiffness, S and tangent modulus, E). Subjects with poor orthokeratology responses had lower E (mean 0.474 MPa) than subjects with good orthokeratology responses (mean 0.536 MPa). Successful orthokeratology for 6 months resulted in reducing CH (reduced by 5.8%) and CRF (reduced by 8.7%). Corneal stiffness was stable, but E showed an increasing trend. Among subjects with successful orthokeratology, a higher baseline S resulted in greater myopia reduction (Pearson correlation coefficient, r = 0.381, p = 0.02).
ISSN: 2045-2322
EISSN: 2045-2322
DOI: 10.1038/s41598-019-49041-z
Rights: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
The following publication Lam, A. K., Hon, Y., Leung, S. Y., Shu-Ho, L., Chong, J., & Lam, D. C. (2019). Association between long-term orthokeratology responses and corneal biomechanics. Scientific reports, 9(1), 1-9, is available at
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