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Title: Effects of maternal voluntary wheel running during pregnancy on adult hippocampal neurogenesis,temporal order memory, and depression-like behavior in adult female and male offspring
Authors: Yau, SY 
Lee, THY 
Formolo, DA 
Lee, WL 
Li, LCK 
Siu, PM
Chan, CCH 
Keywords: Adult neurogenesis
Depression-like behavior
Maternal exercise
Issue Date: 2019
Publisher: Frontiers Research Foundation
Source: Frontiers in neuroscience, 2019, v. 13, no. MAY, 470 How to cite?
Journal: Frontiers in neuroscience 
Abstract: Research suggests that maternal exercise in pregnancy may have beneficial effects on the brain function of offspring. This study sought to determine if voluntary wheel running during pregnancy improves depression-like behavior, temporal order memory, and hippocampal neurogenesis in both female and male offspring mice. Pregnant mice were allowed to run voluntarily by introducing running wheels into the housing cages throughout the gestational period. Male and female mice off spring at the age of 8-to 9-week-old were then tested on the temporal order task and forced swim test, then euthanized for immunostaining for examining adult hippocampal cell proliferation and neuronal differentiation. Results showed that both male and female pups had reduced depression-like behavior, while only male offspring demonstrated improvement in temporal order memory. Immunostaining revealed that male offspring showed an increase in the number of immature neurons in the ventral hippocampus, whereas female offspring showed enhanced cell proliferation in the dorsal hippocampus. These findings indicate that maternal voluntary wheel running benefits both female and male offspring on reducing depression-like behavior, but with gender effect on promoting hippocampal cell proliferation, neuronal differentiation, and temporal order memory.
ISSN: 1662-4548
EISSN: 1662-453X
DOI: 10.3389/fnins.2019.00470
Rights: Copyright © 2019 Yau, Lee, Formolo, Lee, Li, Siu and Chan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The following publication Yau S-Y, Lee TH-Y, Formolo DA, Lee W-L, Li LC-K, Siu PM and Chan CCH (2019) Effects of Maternal Voluntary Wheel Running During Pregnancy on Adult Hippocampal Neurogenesis, Temporal Order Memory, and Depression-Like Behavior in Adult Female and Male Offspring. Front. Neurosci. 13:470 is available at
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