Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81537
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dc.contributor.authorZheng, Zen_US
dc.contributor.authorLi, Ren_US
dc.contributor.authorYe, Len_US
dc.contributor.authorChan, EWCen_US
dc.contributor.authorXia, Xen_US
dc.contributor.authorChen, Sen_US
dc.date.accessioned2019-10-28T05:45:58Z-
dc.date.available2019-10-28T05:45:58Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in microbiology, 2019, v. 10, no. JUN, 1338en_US
dc.identifier.issn1664-302X-
dc.identifier.urihttp://hdl.handle.net/10397/81537-
dc.description.abstractThis study aims to investigate and compare the complete nucleotide sequences of the multidrug resistance plasmids pVb0267 and pVb0499, which were recovered from foodborne Vibrio parahaemolyticus isolates, and analyze the genetic environment of blaCTX-M-55 to provide insight into the dissemination mechanisms of this resistance element. Analysis of the sequences of plasmids pVb0267 (166, 467 bp) and pVb0499 (192, 739 bp) revealed that the backbones of these two plasmids exhibited a high degree of similarity with pR148, a recognized type 1a IncC plasmid recovered from Aeromonas hydrophila (99% identity). The resistance genes, found in both plasmids, included qacH, aadB, arr2, blaOXA-10, aadA1, sul1, tet(A), and blaCTX M-55, which were mostly arranged in a specific region designated ARI-A. Plasmid pVb0499 was found to possess a larger size of ARI-A than pVb0267, which lacked a mer determination region, a qnr A segment, an aacC3 gene and several mobility-encoding genes. Comparative analysis of resistance island (RI) of these plasmids and others revealed the potential evolution route of these RI sequences. In conclusion, plasmids harboring the blaCTX M-55 gene has been recovered in Vibrio parahaemolyticus strains of food origin. It is alarming to find that IncC plasmids harboring resistance islands are disseminating in aquatic bacterial strains. The continuous evolution of resistance genes in conjugative plasmid in aquatic bacteria could be due to bacterial adaption to aquaculture environment, where antibiotics were increasingly used.en_US
dc.description.sponsorshipDepartment of Applied Biology and Chemical Technologyen_US
dc.language.isoenen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.ispartofFrontiers in microbiologyen_US
dc.rightsCopyright © 2019 Zheng, Li, Ye, Wai-chi Chan, Xia and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rightsThe following publication Zheng Z, Li R, Ye L, Wai-chi Chan E, Xia X and Chen S (2019) Genetic Characterization of blaCTX-M-55 -Bearing Plasmids Harbored by Food-Borne Cephalosporin-Resistant Vibrio parahaemolyticus Strains in China. Front. Microbiol. 10:1338, is available at https://doi.org/10.3389/fmicb.2019.01338en_US
dc.subjectblaCTX-M-55en_US
dc.subjectCephalosporin resistanceen_US
dc.subjectConjugative plasmiden_US
dc.subjectIncC plasmiden_US
dc.subjectV. parahaemolyticusen_US
dc.titleGenetic characterization of blaCTX-M-55-bearing plasmids harbored by food-borne cephalosporin-resistant Vibrio parahaemolyticus Strains in Chinaen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.volume10-
dc.identifier.issueJUN-
dc.identifier.doi10.3389/fmicb.2019.01338-
dc.identifier.scopus2-s2.0-85069161239-
dc.identifier.artn1338-
dc.description.validate201910 bcma-
dc.description.oapublished_final-
Appears in Collections:Journal/Magazine Article
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