Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/81520
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Kautzky, A | en_US |
dc.creator | Dold, M | en_US |
dc.creator | Bartova, L | en_US |
dc.creator | Spies, M | en_US |
dc.creator | Kranz, GS | en_US |
dc.creator | Souery, D | en_US |
dc.creator | Montgomery, S | en_US |
dc.creator | Mendlewicz, J | en_US |
dc.creator | Zohar, J | en_US |
dc.creator | Fabbri, C | en_US |
dc.creator | Serretti, A | en_US |
dc.creator | Lanzenberger, R | en_US |
dc.creator | Dikeos, D | en_US |
dc.creator | Rujescu, D | en_US |
dc.creator | Kasper, S | en_US |
dc.date.accessioned | 2019-10-28T05:45:53Z | - |
dc.date.available | 2019-10-28T05:45:53Z | - |
dc.identifier.issn | 0001-690X | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/81520 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | © 2018 The Authors Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights | The following publication Kautzky, A., Dold, M., Bartova, L., Spies, M., Kranz, G. S., Souery, D., ... & Serretti, A. (2019). Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study. Acta Psychiatrica Scandinavica, 139(1), 78-88 is available at https://doi.org/10.1111/acps.12959 | en_US |
dc.subject | Antidepressives | en_US |
dc.subject | Clinical aspects | en_US |
dc.subject | Depression | en_US |
dc.title | Clinical factors predicting treatment resistant depression : affirmative results from the European multicenter study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 78 | en_US |
dc.identifier.epage | 88 | en_US |
dc.identifier.volume | 139 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.doi | 10.1111/acps.12959 | en_US |
dcterms.abstract | Objectives: Clinical variables were investigated in the ‘treatment resistant depression (TRD)- III’ sample to replicate earlier findings by the European research consortium ‘Group for the Study of Resistant Depression’ (GSRD) and enable cross-sample prediction of treatment outcome in TRD. | en_US |
dcterms.abstract | Experimental procedures: TRD was defined by a Montgomery and Åsberg Depression Rating Scale (MADRS) score ≥22 after at least two antidepressive trials. Response was defined by a decline in MADRS score by ≥50% and below a threshold of 22. Logistic regression was applied to replicate predictors for TRD among 16 clinical variables in 916 patients. Elastic net regression was applied for prediction of treatment outcome. | en_US |
dcterms.abstract | Results: Symptom severity (odds ratio (OR) = 3.31), psychotic symptoms (OR = 2.52), suicidal risk (OR = 1.74), generalized anxiety disorder (OR = 1.68), inpatient status (OR = 1.65), higher number of antidepressants administered previously (OR = 1.23), and lifetime depressive episodes (OR = 1.15) as well as longer duration of the current episode (OR = 1.022) increased the risk of TRD. Prediction of TRD reached an accuracy of 0.86 in the independent validation set, TRD-I. | en_US |
dcterms.abstract | Conclusion: Symptom severity, suicidal risk, higher number of lifetime depressive episodes, and comorbid anxiety disorder were replicated as the most prominent risk factors for TRD. Significant predictors in TRD-III enabled robust prediction of treatment outcome in TRD-I. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Acta psychiatrica Scandinavica, Jan. 2019, v. 139, no. 1, p. 78-88 | en_US |
dcterms.isPartOf | Acta psychiatrica Scandinavica | en_US |
dcterms.issued | 2019-01 | - |
dc.identifier.scopus | 2-s2.0-85054472097 | - |
dc.identifier.eissn | 1600-0447 | en_US |
dc.description.validate | 201910 bcma | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a0800-n02, OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Austrian Science Fund (FWF) grant numbers P27141 and KLI 516, no PGMS number. | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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Kautzky_Clinical_factors_predicting.pdf | 254.1 kB | Adobe PDF | View/Open |
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