Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81520
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dc.contributor.authorKautzky, Aen_US
dc.contributor.authorDold, Men_US
dc.contributor.authorBartova, Len_US
dc.contributor.authorSpies, Men_US
dc.contributor.authorKranz, GSen_US
dc.contributor.authorSouery, Den_US
dc.contributor.authorMontgomery, Sen_US
dc.contributor.authorMendlewicz, Jen_US
dc.contributor.authorZohar, Jen_US
dc.contributor.authorFabbri, Cen_US
dc.contributor.authorSerretti, Aen_US
dc.contributor.authorLanzenberger, Ren_US
dc.contributor.authorDikeos, Den_US
dc.contributor.authorRujescu, Den_US
dc.contributor.authorKasper, Sen_US
dc.date.accessioned2019-10-28T05:45:53Z-
dc.date.available2019-10-28T05:45:53Z-
dc.date.issued2018-
dc.identifier.citationActa psychiatrica Scandinavica, 2018, v. 139, no. 1, p. 78-88en_US
dc.identifier.issn0001-690X-
dc.identifier.urihttp://hdl.handle.net/10397/81520-
dc.description.abstractObjectives: Clinical variables were investigated in the ‘treatment resistant depression (TRD)- III’ sample to replicate earlier findings by the European research consortium ‘Group for the Study of Resistant Depression’ (GSRD) and enable cross-sample prediction of treatment outcome in TRD.en_US
dc.description.abstractExperimental procedures: TRD was defined by a Montgomery and Åsberg Depression Rating Scale (MADRS) score ≥22 after at least two antidepressive trials. Response was defined by a decline in MADRS score by ≥50% and below a threshold of 22. Logistic regression was applied to replicate predictors for TRD among 16 clinical variables in 916 patients. Elastic net regression was applied for prediction of treatment outcome.en_US
dc.description.abstractResults: Symptom severity (odds ratio (OR) = 3.31), psychotic symptoms (OR = 2.52), suicidal risk (OR = 1.74), generalized anxiety disorder (OR = 1.68), inpatient status (OR = 1.65), higher number of antidepressants administered previously (OR = 1.23), and lifetime depressive episodes (OR = 1.15) as well as longer duration of the current episode (OR = 1.022) increased the risk of TRD. Prediction of TRD reached an accuracy of 0.86 in the independent validation set, TRD-I.en_US
dc.description.abstractConclusion: Symptom severity, suicidal risk, higher number of lifetime depressive episodes, and comorbid anxiety disorder were replicated as the most prominent risk factors for TRD. Significant predictors in TRD-III enabled robust prediction of treatment outcome in TRD-I.en_US
dc.description.sponsorshipDepartment of Rehabilitation Sciencesen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa psychiatrica Scandinavicaen_US
dc.rights© 2018 The Authors Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rightsThe following publication Kautzky, A., Dold, M., Bartova, L., Spies, M., Kranz, G. S., Souery, D., ... & Serretti, A. (2019). Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study. Acta Psychiatrica Scandinavica, 139(1), 78-88 is available at https://doi.org/10.1111/acps.12959en_US
dc.subjectAntidepressivesen_US
dc.subjectClinical aspectsen_US
dc.subjectDepressionen_US
dc.titleClinical factors predicting treatment resistant depression : affirmative results from the European multicenter studyen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage78-
dc.identifier.epage88-
dc.identifier.volume139-
dc.identifier.issue1-
dc.identifier.doi10.1111/acps.12959-
dc.identifier.scopus2-s2.0-85054472097-
dc.identifier.eissn1600-0447-
dc.description.validate201910 bcma-
dc.description.oapublished_final-
Appears in Collections:Journal/Magazine Article
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