Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/81342
Title: Defocused image changes signaling of ganglion cells in the mouse retina
Authors: Pan, F 
Keywords: Ganglion cell
Myopia
Signaling
Gap junction
Retina
Issue Date: 2019
Publisher: Molecular Diversity Preservation International (MDPI)
Source: Cells, July 2019, v. 8, no. 7, 640, p. 1-21 How to cite?
Journal: Cells 
Abstract: Myopia is a substantial public health problem worldwide. Although it is known that defocused images alter eye growth and refraction, their effects on retinal ganglion cell (RGC) signaling that lead to either emmetropization or refractive errors have remained elusive. This study aimed to determine if defocused images had an effect on signaling of RGCs in the mouse retina. ON and OFF alpha RGCs and ON OFF RGCs were recorded from adult C57BL/6J wild-type mice. A mono green organic light-emitting display presented images generated by PsychoPy. The defocused images were projected on the retina under a microscope. Dark-adapted mouse RGCs were recorded under different powers of projected defocused images on the retina. Compared with focused images, defocused images showed a significantly decreased probability of spikes. More than half of OFF transient RGCs and ON sustained RGCs showed disparity in responses to the magnitude of plus and minus optical defocus (although remained RGCs we tested exhibited similar response to both types of defocus). ON and OFF units of ON OFF RGCs also responded differently in the probability of spikes to defocused images and spatial frequency images. After application of a gap junction blocker, the probability of spikes of RGCs decreased with the presence of optical defocused image. At the same time, the RGCs also showed increased background noise. Therefore, defocused images changed the signaling of some ON and OFF alpha RGCs and ON OFF RGCs in the mouse retina. The process may be the first step in the induction of myopia development. It appears that gap junctions also play a key role in this process.
URI: http://hdl.handle.net/10397/81342
EISSN: 2073-4409
DOI: 10.3390/cells8070640
Rights: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
The following publication Pan, F. Defocused Image Changes Signaling of Ganglion Cells in the Mouse Retina. Cells 2019, 8, 640, 1-21 is available at https://dx.doi.org/10.3390/cells8070640
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Pan_Defocused_Image_Changes.pdf1.73 MBAdobe PDFView/Open
Access
View full-text via PolyU eLinks SFX Query
Show full item record
PIRA download icon_1.1View/Download Contents

Page view(s)

10
Citations as of Oct 22, 2019

Download(s)

6
Citations as of Oct 22, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.