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Title: Repeatability of choroidal thickness measurements with Spectralis OCT images
Authors: Lau, JK 
Cheung, SW 
Collins, MJ
Cho, P 
Issue Date: 2019
Publisher: BMJ Group
Source: BMJ Open ophthalmology, Jan. 2019, v. 4, no. 1, e000237, p. 1-7 How to cite?
Journal: BMJ Open ophthalmology 
Abstract: Objective To investigate the repeatability of choroidal thickness measurements determined from enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes after wearing single-vision spectacles (SV) and orthokeratology (ortho-k) lenses.
Methods and analysis Two EDI-OCT images of 40 children (SV: 20, ortho-k: 20) taken at a single visit were analysed twice. Subjects in the ortho-k group had been wearing ortho-k for 1-4 weeks. The choroidal thickness was determined from each image using a graph theory-based software and, where appropriate, manual correction of choroidal boundaries was undertaken by an experienced examiner.
Results The mean (+/- SD) choroidal thickness was 227.3 +/- 42.2 mu m for the SV subjects and 251.1 +/- 54.4 mu m for the ortho-k subjects. The interimage differences in choroidal thickness were -0.99 +/- 3.54 and -1.14 +/- 5.03 mu m for the SV and ortho-k subjects, respectively, and the limits of agreement were +5.96 to -7.93 and +8.72 to -11.00 mu m, respectively.
Conclusion The coefficients of repeatability of choroidal thickness measurements from two EDI-OCT images taken at a single visit were 7.08 mu m (SV) and 10.06 mu m (ortho-k), suggesting that a change in choroidal thickness of less than 10 mu m may not indicate a real change resulting from ortho-k lens wear.
EISSN: 2397-3269
DOI: 10.1136/bmjophth-2018-000237
Rights: © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:
The following publication Lau JK, Cheung SW, Collins MJ, et al. Repeatability of choroidal thickness measurements with Spectralis OCT images. BMJ Open Ophthalmology 2019;4:e000237; 7 pages is available at
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