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Title: Acutherapy for knee osteoarthritis relief in the elderly : a systematic review and meta-analysis
Authors: Gong, ZD 
Liu, R 
Yu, WN 
Wong, TKS
Guo, YQ
Sun, Y 
Issue Date: 2019
Publisher: Hindawi Publishing Corporation
Source: Evidence-based complementary and alternative medicine, 2019, 1868107, p. 1-13 How to cite?
Journal: Evidence-based complementary and alternative medicine 
Abstract: Purpose. This systematic review and meta-analysis was conducted to investigate the effects of various acutherapies on knee osteoarthritis (KOA) relief in the elderly.
Methods. Five databases were accessed from inception to July 2017 for searching randomized controlled trials (RCTs) on acutherapy for KOA relief in the elderly. Data were pooled after trial quality assessment for meta-analysis. Outcomes were the scores of knee pain, knee stiffness, and physical function accessed by Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index.
Results. 17 RCTs including 4774 subjects were included. The results indicated that acutherapy significantly affected knee pain (standardized mean difference, i.e., SMD = - 0.73, [95% CI, -0.98 to -0.47], P <0.001), knee stiffness (SMD = -0.66, [95%CI, -0.85 to -0.47], P <0.001), and physical function (SMD = -1.56, [95%CI, -2.17 to -0.95], P<0.001) when compared with control condition without intervention of any acutherapy. Moreover, acutherapy was more effective than corresponding sham (placebo) intervention applied on nonacupoints (SMD = -0.16, [95% CI, -0.32 to -0.01], P = 0.04). However, no significant differences were found on treatment effects between acutherapy and sham acutherapy at the same acupoints (SMD= - 0.09, [95%CI, -0.40 to 0.21], P = 0.55).
Conclusions. Acutherapy was an effective approach for KOA relief in the elderly. The selection of acupoints position could be a crucial factor that influences the treatment efficacy of acutherapy.
ISSN: 1741-427X
EISSN: 1741-4288
DOI: 10.1155/2019/1868107
Rights: Copyright © 2019 Zidan Gong et al. This is an open access article distributed under the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following publication Zidan Gong, Rong Liu, Winnie Yu, Thomas Kwok-Shing Wong, Yuanqi Guo, and Yue Sun, “Acutherapy for Knee Osteoarthritis Relief in the Elderly: A Systematic Review and Meta-Analysis,” Evidence-Based Complementary and Alternative Medicine, vol. 2019, Article ID 1868107, 13 pages, 2019 is available at
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