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Title: Association between osteoarthritis and increased risk of dementia : a systemic review and meta-analysis
Authors: Weber, A 
Mak, SH 
Berenbaum, F
Sellam, J
Zheng, YP 
Han, YF 
Wen, CY 
Keywords: Dementia
Systematic review
Issue Date: 2019
Publisher: Lippincott Williams & Wilkins
Source: Medicine, Mar. 2019, v. 98, no. 10, e14355, p. 1-8 How to cite?
Journal: Medicine 
Abstract: Objective: To investigate the possible association between osteoarthritis (OA) and the risk of dementia.
Methods: Cohort, case-control, and cross-sectional studies were obtained from wide literature search up to 20 April 2018 from following electronic databases: PubMed, Embase, Cochrane, using the MeSH terms: osteoarthritis AND dementia. The literature search was then expanded to congress abstracts. After screening and selection of relevant studies by two investigators, data was extracted. Estimates were then calculated using a random-effect size model. Sensitivity-analysis was conducted for gender and age adjusted studies and pooled for studies with STROBE quality assessment score 75%. Publication bias was assessed by Funnel plot. Analyses were performed using Data Analysis and Statistical Software Version 14.2.
Results: Nearly 1549 publication references were initially retrieved. Twenty-six publications were checked with full-text. Six observational studies with 388,252 individuals were included. OA was associated with a significantly increased risk for dementia (OR=1.20; 95% confidence interval (CI), 1.03-1.39, I-2=95.6%, P<.05). After pooling the studies with adjustment of age and gender, the risk increased (OR 1.36; 95% CI, 1.22-1.51, I-2=75.6%, P<.0001). After pooling the study with a STROBE Quality score 75% the risk for dementia was slightly increased (OR 1.33; 95% CI, 1.17-1.5, I-2=93.5%, p<0.0001).
Conclusions: There is an association between osteoarthritis and the risk of dementia. This meta-analysis does not provide causality. Further prospective cohort studies are needed to clarify, if knee-, hip-, or hand-OA are independent risk factors for Alzheimer's disease and vascular dementia.
ISSN: 0025-7974
EISSN: 1536-5964
DOI: 10.1097/MD.0000000000014355
Rights: Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.
This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND)(, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
The following publication Weber, A., Mak, S. H., Berenbaum, F., Sellam, J., Zheng, Y. P., Han, Y., & Wen, C. (2019). Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis. Medicine, 98(10):e14355, 1-8 is available at
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