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Title: Evolution and transmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance in salmonella
Authors: Chen, KC 
Chan, EWC 
Chen, S 
Keywords: Salmonella
Ciprofloxacin resistance
Ceftriaxone resistance
PMQR genes
Conjugative plasmid
Issue Date: 2019
Publisher: Nature Publishing Group
Source: Emerging microbes & infections, 21 Mar. 2019, v. 8, no. 1, p. 396-403 How to cite?
Journal: Emerging microbes & infections 
Abstract: Ceftriaxone and ciprofloxacin are the drugs of choice in treatment of invasive Salmonella infections. This study discovered a novel type of plasmid, pSa44-CIP-CRO, which was recovered from a S. London strain isolated from meat product and comprised genetic determinants that encoded resistance to both ciprofloxacin and ceftriaxone. This plasmid could be resolved into two daughter plasmids and co-exist with such daughter plasmids in a dynamic form in Salmonella; yet it was only present as a single plasmid in Escherichia coli. One daughter plasmid, pSa44-CRO, was found to carry the bla(CTX-M-130) gene, which encodes resistance to ceftriaxone, whereas the other plasmid, pSa44-CIP, carried multiple PMQR genes such as qnrB6-aac(6')-Ib-cr, which mediated resistance to ciprofloxacin. These two daughter plasmids could be integrated into one single plasmid through ISPa40 mediated homologous recombination. Mouse infection and treatment experiments showed that carriage of plasmid, pSa44-CIP-CRO by S. typhimurium led to the impairment of treatment by ciprofloxacin or cefitiofur, a veterinary drug with similar properties as ceftriaxone. In conclusion, dissemination of such conjugative plasmids impairs current choices of treatment for life-threatening Salmonella infection and hence constitutes a serious public health threat.
EISSN: 2222-1751
DOI: 10.1080/22221751.2019.1585965
Rights: © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following publication Kaichao Chen, Edward Wai Chi Chan & Sheng Chen (2019) Evolution andtransmission of a conjugative plasmid encoding both ciprofloxacin and ceftriaxone resistance inSalmonella, Emerging Microbes & Infections, 8:1, 396-403 is available at
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