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Title: Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry
Authors: Ng, TT 
So, PK 
Hu, B 
Yao, ZP 
Keywords: Drugs-of-abuse
Wooden tips
Body fluid
Issue Date: 2019
Publisher: Elsevier
Source: Journal of food and drug analysis (藥物食品分析), Apr. 2019, v. 27, no. 2, p. 428-438 How to cite?
Journal: Journal of food and drug analysis (藥物食品分析) 
Abstract: Determination of drugs-of-abuse in body fluids of drug abusers is important for the law enforcement as well as the treatment and rehabilitation. In this study, wooden-tip electrospray ionization mass spectrometry (WT-ESI-MS), a simple and cost-effective technique, was developed for rapid detection and quantitation of common drugs-of-abuse, including methamphetamine, methylenedioxymethamphetamine (MDMA), cocaine, heroin and tetrahydrocannabinol (THC), in urine and oral fluid, following our previous successful demonstration for rapid and sensitive detection of ketamine and nor-ketamine in urine and oral fluid by this technique. It was found that the limit-of-detection for methamphetamine could fully fulfill the cut-off value requirements of the international standards, and those of MDMA and cocaine could fulfill some of the requirements. The linear range, accuracy and precision for quantitation of the drugs were generally satisfactory, except for THC for which the analytical performance still needs to be improved. Analysis of one sample could typically be completed within minutes. These results indicated that WT-ESI-MS could be used for rapid screening of drugs-of-abuse in urine, oral fluid as well as other body fluids.
EISSN: 1021-9498
DOI: 10.1016/j.jfda.2018.09.002
Rights: Copyright © 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. This is an open access article under the CCBY-NC-ND license (
The following publication Ng, T. T., So, P. K., Hu, B., & Yao, Z. P. (2018). Rapid detection and quantitation of drugs-of-abuse by wooden-tip electrospray ionization mass spectrometry. Journal of food and drug analysis, 27(2), 428-438 is available at
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